A new graphic for quality adjusted life years (Q-TWiST) survival analysis: The Q-TWiST plot

Jeff A. Sloan, Daniel J. Sargent, Jed Lindman, Cristine Allmer, Delfino Vargas-Chanes, Edward T. Creagan, James A. Bonner, Michael J. O'Connell, Robert J. Dalton, Kendrith M. Rowland, Burke J. Brooks, John A. Laurie

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

One of the challenges of interpreting a Quality-adjusted time without symptoms of disease and toxicity (Q-TWiST) analysis is examining the sensitivity of conclusions that may be drawn to varying values of the utility coefficients for days with toxicity and days after disease progression. We present a graphic that parsimoniously displays the impact on median Q-TWiST survival across treatment groups of varying values of the utility coefficients. The goal of the graphic is to present a concise Q-TWiST analysis. We use Zhao and Tsiatis (Biometrika 1997; 84(2): 339-348) to adjust for the bias in Kaplan-Meier (K-M) estimates. The graphic contains bounds that approximate points for which statistical significance would be achieved by comparing the median Q-TWiST survival between treatment alternatives for each value of the utility coefficients. The plot may be generalized to compare Q-TWiST means, medians or percentiles across treatment groups. We demonstrate the application of the Q-TWiST plot through a re-analysis of a randomized phase III North Central Cancer Treatment Group (NCCTG) clinical trial of recombinant Interferon-2α in patients with malignant melanoma. We explore alternative options to customize the graphic representation for other data sets drawn from several NCCTG clinical trials.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalQuality of Life Research
Volume11
Issue number1
DOIs
StatePublished - Apr 20 2002

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Keywords

  • Kaplan-Meier estimates
  • Q-TWiST
  • Survival analysis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Sloan, J. A., Sargent, D. J., Lindman, J., Allmer, C., Vargas-Chanes, D., Creagan, E. T., Bonner, J. A., O'Connell, M. J., Dalton, R. J., Rowland, K. M., Brooks, B. J., & Laurie, J. A. (2002). A new graphic for quality adjusted life years (Q-TWiST) survival analysis: The Q-TWiST plot. Quality of Life Research, 11(1), 37-45. https://doi.org/10.1023/A:1014401516011