A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management

Christian L. Baum, Adam C. Wright, Juan Carlos Martinez, Christopher J. Arpey, Jerry D. Brewer, Randall K. Roenigk, Clark C. Otley

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume78
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • cutaneous squamous cell carcinoma
  • immunosuppression
  • management
  • radiotherapy
  • risk stratification
  • sentinel lymph node biopsy
  • staging

ASJC Scopus subject areas

  • Dermatology

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