A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management

Christian Baum; Adam C. Wright; Juan Carlos Martinez; Christopher J. Arpey; Jerry D. Brewer; Randall K. Roenigk; Clark C. Otley

doi:10.1016/j.jaad.2017.07.031

A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management

Christian Baum, Adam C. Wright, Juan Carlos Martinez, Christopher J. Arpey, Jerry D. Brewer, Randall K. Roenigk, Clark C. Otley

Dermatology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse.

Original language	English (US)
Journal	Journal of the American Academy of Dermatology
DOIs	https://doi.org/10.1016/j.jaad.2017.07.031
State	Accepted/In press - 2017

Keywords

Cutaneous squamous cell carcinoma
Immunosuppression
Management
Radiotherapy
Risk stratification
Sentinel lymph node biopsy
Staging

ASJC Scopus subject areas

Dermatology

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Baum, C., Wright, A. C., Martinez, J. C., Arpey, C. J., Brewer, J. D., Roenigk, R. K., & Otley, C. C. (Accepted/In press). A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management. Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2017.07.031

A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management. / Baum, Christian; Wright, Adam C.; Martinez, Juan Carlos; Arpey, Christopher J.; Brewer, Jerry D.; Roenigk, Randall K.; Otley, Clark C.

In: Journal of the American Academy of Dermatology, 2017.

Research output: Contribution to journal › Article › peer-review

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abstract = "Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse.",

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AU - Roenigk, Randall K.

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AB - Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse.

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