A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management

Christian L. Baum; Adam C. Wright; Juan Carlos Martinez; Christopher J. Arpey; Jerry D. Brewer; Randall K. Roenigk; Clark C. Otley

doi:10.1016/j.jaad.2017.07.031

A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management

Christian L. Baum, Adam C. Wright, Juan Carlos Martinez, Christopher J. Arpey, Jerry D. Brewer, Randall K. Roenigk, Clark C. Otley

Dermatology

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse.

Original language	English (US)
Pages (from-to)	141-147
Number of pages	7
Journal	Journal of the American Academy of Dermatology
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/j.jaad.2017.07.031
State	Published - Jan 2018

Keywords

cutaneous squamous cell carcinoma
immunosuppression
management
radiotherapy
risk stratification
sentinel lymph node biopsy
staging

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2017.07.031

Cite this

Baum, C. L., Wright, A. C., Martinez, J. C., Arpey, C. J., Brewer, J. D., Roenigk, R. K., & Otley, C. C. (2018). A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management. Journal of the American Academy of Dermatology, 78(1), 141-147. https://doi.org/10.1016/j.jaad.2017.07.031

A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management. / Baum, Christian L.; Wright, Adam C.; Martinez, Juan Carlos; Arpey, Christopher J.; Brewer, Jerry D.; Roenigk, Randall K.; Otley, Clark C.

In: Journal of the American Academy of Dermatology, Vol. 78, No. 1, 01.2018, p. 141-147.

Research output: Contribution to journal › Review article › peer-review

Baum, CL, Wright, AC, Martinez, JC, Arpey, CJ, Brewer, JD, Roenigk, RK & Otley, CC 2018, 'A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management', Journal of the American Academy of Dermatology, vol. 78, no. 1, pp. 141-147. https://doi.org/10.1016/j.jaad.2017.07.031

Baum, Christian L. ; Wright, Adam C. ; Martinez, Juan Carlos ; Arpey, Christopher J. ; Brewer, Jerry D. ; Roenigk, Randall K. ; Otley, Clark C. / A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management. In: Journal of the American Academy of Dermatology. 2018 ; Vol. 78, No. 1. pp. 141-147.

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abstract = "Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse.",

keywords = "cutaneous squamous cell carcinoma, immunosuppression, management, radiotherapy, risk stratification, sentinel lymph node biopsy, staging",

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note = "Funding Information: Funding sources: Dr Baum has a Career Development Award in Dermatologic Surgery from the Dermatology Foundation. Publisher Copyright: {\textcopyright} 2017 American Academy of Dermatology, Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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AU - Roenigk, Randall K.

AU - Otley, Clark C.

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AB - Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse.

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A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management

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