A neuronal antigen in the brains of Alzheimer patients

B. L. Wolozin, A. Pruchnicki, Dennis W Dickson, P. Davies

Research output: Contribution to journalArticle

486 Scopus citations

Abstract

A monoclonal antibody was prepared against pooled homogenates of brain tisue from patients with Alheimer's disease'. This antibody recognizes an antigen present in much higher concentration in certain brain regions of Alzheimer patients than in normal brain. The antigen appears to be a protein present in neurons involved in the formation of neuritic plaques and neurofibrillary tangles, and in some morphologically normal neurons in sections from Alzheimer brains. Partial purification and Western blot analysis revealed the antigen from Alzheimer brain to be a single protein with a molecular weight of 68,000. Applications of the same purification procedure to normal brain tissue results in the detection of small amounts of a protein of lower molecular weight.

Original languageEnglish (US)
Pages (from-to)648-650
Number of pages3
JournalScience
Volume232
Issue number4750
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'A neuronal antigen in the brains of Alzheimer patients'. Together they form a unique fingerprint.

  • Cite this

    Wolozin, B. L., Pruchnicki, A., Dickson, D. W., & Davies, P. (1986). A neuronal antigen in the brains of Alzheimer patients. Science, 232(4750), 648-650.