A neuronal antigen in the brains of Alzheimer patients

Benjamin L. Wolozin; Alex Pruchnicki; Dennis W. Dickson; Peter Davies

doi:10.1126/science.3083509

A neuronal antigen in the brains of Alzheimer patients

Benjamin L. Wolozin, Alex Pruchnicki, Dennis W. Dickson, Peter Davies

Neuroscience

Research output: Contribution to journal › Article › peer-review

492 Scopus citations

Abstract

A monoclonal antibody was prepared against pooled homogenates of brain tissue from patients with Alzheimer's disease. This antibody recognizes an antigen present in much higher concentration in certain brain regions of Alzheimer patients than in normal brain. The antigen appears to be a protein present in neurons involved in the formation of neuritic plaques and neurofibrillary tangles, and in some morphologically normal neurons in sections from Alzheimer brains. Partial purification and Western blot analysis revealed the antigen from Alzheimer brain to be a single protein with a molecular weight of 68,000. Application of the same purification procedure to normal brain tissue results in the detection of small amounts of a protein of lower molecular weight.

Original language	English (US)
Pages (from-to)	648-650
Number of pages	3
Journal	Science
Volume	232
Issue number	4750
DOIs	https://doi.org/10.1126/science.3083509
State	Published - 1986

ASJC Scopus subject areas

General

Access to Document

10.1126/science.3083509

Cite this

@article{6d125fa528ae41279592c11d44cd5d43,

title = "A neuronal antigen in the brains of Alzheimer patients",

abstract = "A monoclonal antibody was prepared against pooled homogenates of brain tissue from patients with Alzheimer's disease. This antibody recognizes an antigen present in much higher concentration in certain brain regions of Alzheimer patients than in normal brain. The antigen appears to be a protein present in neurons involved in the formation of neuritic plaques and neurofibrillary tangles, and in some morphologically normal neurons in sections from Alzheimer brains. Partial purification and Western blot analysis revealed the antigen from Alzheimer brain to be a single protein with a molecular weight of 68,000. Application of the same purification procedure to normal brain tissue results in the detection of small amounts of a protein of lower molecular weight.",

author = "Wolozin, {Benjamin L.} and Alex Pruchnicki and Dickson, {Dennis W.} and Peter Davies",

year = "1986",

doi = "10.1126/science.3083509",

language = "English (US)",

volume = "232",

pages = "648--650",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4750",

}

TY - JOUR

T1 - A neuronal antigen in the brains of Alzheimer patients

AU - Wolozin, Benjamin L.

AU - Pruchnicki, Alex

AU - Dickson, Dennis W.

AU - Davies, Peter

PY - 1986

Y1 - 1986

N2 - A monoclonal antibody was prepared against pooled homogenates of brain tissue from patients with Alzheimer's disease. This antibody recognizes an antigen present in much higher concentration in certain brain regions of Alzheimer patients than in normal brain. The antigen appears to be a protein present in neurons involved in the formation of neuritic plaques and neurofibrillary tangles, and in some morphologically normal neurons in sections from Alzheimer brains. Partial purification and Western blot analysis revealed the antigen from Alzheimer brain to be a single protein with a molecular weight of 68,000. Application of the same purification procedure to normal brain tissue results in the detection of small amounts of a protein of lower molecular weight.

AB - A monoclonal antibody was prepared against pooled homogenates of brain tissue from patients with Alzheimer's disease. This antibody recognizes an antigen present in much higher concentration in certain brain regions of Alzheimer patients than in normal brain. The antigen appears to be a protein present in neurons involved in the formation of neuritic plaques and neurofibrillary tangles, and in some morphologically normal neurons in sections from Alzheimer brains. Partial purification and Western blot analysis revealed the antigen from Alzheimer brain to be a single protein with a molecular weight of 68,000. Application of the same purification procedure to normal brain tissue results in the detection of small amounts of a protein of lower molecular weight.

UR - http://www.scopus.com/inward/record.url?scp=0022457104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022457104&partnerID=8YFLogxK

U2 - 10.1126/science.3083509

DO - 10.1126/science.3083509

M3 - Article

C2 - 3083509

AN - SCOPUS:0022457104

SN - 0036-8075

VL - 232

SP - 648

EP - 650

JO - Science

JF - Science

IS - 4750

ER -

A neuronal antigen in the brains of Alzheimer patients

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this