A neuronal antigen in the brains of Alzheimer patients

B. L. Wolozin, A. Pruchnicki, Dennis W Dickson, P. Davies

Research output: Contribution to journalArticle

478 Citations (Scopus)

Abstract

A monoclonal antibody was prepared against pooled homogenates of brain tisue from patients with Alheimer's disease'. This antibody recognizes an antigen present in much higher concentration in certain brain regions of Alzheimer patients than in normal brain. The antigen appears to be a protein present in neurons involved in the formation of neuritic plaques and neurofibrillary tangles, and in some morphologically normal neurons in sections from Alzheimer brains. Partial purification and Western blot analysis revealed the antigen from Alzheimer brain to be a single protein with a molecular weight of 68,000. Applications of the same purification procedure to normal brain tissue results in the detection of small amounts of a protein of lower molecular weight.

Original languageEnglish (US)
Pages (from-to)648-650
Number of pages3
JournalScience
Volume232
Issue number4750
StatePublished - 1986
Externally publishedYes

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Antigens
Brain
Molecular Weight
Neurons
Neurofibrillary Tangles
Proteins
Amyloid Plaques
Western Blotting
Monoclonal Antibodies
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Wolozin, B. L., Pruchnicki, A., Dickson, D. W., & Davies, P. (1986). A neuronal antigen in the brains of Alzheimer patients. Science, 232(4750), 648-650.

A neuronal antigen in the brains of Alzheimer patients. / Wolozin, B. L.; Pruchnicki, A.; Dickson, Dennis W; Davies, P.

In: Science, Vol. 232, No. 4750, 1986, p. 648-650.

Research output: Contribution to journalArticle

Wolozin, BL, Pruchnicki, A, Dickson, DW & Davies, P 1986, 'A neuronal antigen in the brains of Alzheimer patients', Science, vol. 232, no. 4750, pp. 648-650.
Wolozin BL, Pruchnicki A, Dickson DW, Davies P. A neuronal antigen in the brains of Alzheimer patients. Science. 1986;232(4750):648-650.
Wolozin, B. L. ; Pruchnicki, A. ; Dickson, Dennis W ; Davies, P. / A neuronal antigen in the brains of Alzheimer patients. In: Science. 1986 ; Vol. 232, No. 4750. pp. 648-650.
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