A network map of Interleukin-10 signaling pathway

Renu Verma, Lavanya Balakrishnan, Kusum Sharma, Aafaque Ahmad Khan, Jayshree Advani, Harsha Gowda, Srikanth Prasad Tripathy, Mrutyunjay Suar, Akhilesh Pandey, Sheetal Gandotra, T. S.Keshava Prasad, Subramanian Shankar

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalJournal of Cell Communication and Signaling
Volume10
Issue number1
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Keywords

  • Co-stimulatory molecules
  • Interferon-gamma (IFN-γ)
  • Lipopolysaccharides
  • NetSlim
  • Pro-inflammatory cytokines
  • Protein-protein interactions
  • Systems biology markup language
  • Translocation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Verma, R., Balakrishnan, L., Sharma, K., Khan, A. A., Advani, J., Gowda, H., Tripathy, S. P., Suar, M., Pandey, A., Gandotra, S., Prasad, T. S. K., & Shankar, S. (2016). A network map of Interleukin-10 signaling pathway. Journal of Cell Communication and Signaling, 10(1), 61-67. https://doi.org/10.1007/s12079-015-0302-x