A network map of IL-33 signaling pathway

Sneha M. Pinto, Yashwanth Subbannayya, D. A.B. Rex, Rajesh Raju, Oishi Chatterjee, Jayshree Advani, Aneesha Radhakrishnan, T. S. Keshava Prasad, Mohan R. Wani, Akhilesh Pandey

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central role in the regulation of immune responses. Its release from epithelial and endothelial cells is mediated by pro-inflammatory cytokines, cell damage and by recognition of pathogen-associated molecular patterns (PAMPs). The activity of IL-33 is mediated by binding to the IL-33 receptor complex (IL-33R) and activation of NF-κB signaling via the classical MyD88/IRAK/TRAF6 module. IL-33 also induces the phosphorylation and activation of ERK1/2, JNK, p38 and PI3K/AKT signaling modules resulting in the production and release of pro-inflammatory cytokines. Aberrant signaling by IL-33 has been implicated in the pathogenesis of several acute and chronic inflammatory diseases, including asthma, atopic dermatitis, rheumatoid arthritis and ulcerative colitis among others. Considering the biomedical importance of IL-33, we developed a pathway resource of signaling events mediated by IL-33/IL-33R in this study. Using data mined from the published literature, we describe an integrated pathway reaction map of IL-33/IL-33R consisting of 681 proteins and 765 reactions. These include information pertaining to 19 physical interaction events, 740 enzyme catalysis events, 6 protein translocation events, 4 activation/inhibition events, 9 transcriptional regulators and 2492 gene regulation events. The pathway map is publicly available through NetPath (http://www.netpath.org/), a resource of human signaling pathways developed previously by our group. This resource will provide a platform to the scientific community in facilitating identification of novel therapeutic targets for diseases associated with dysregulated IL-33 signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_120.

Original languageEnglish (US)
Pages (from-to)615-624
Number of pages10
JournalJournal of Cell Communication and Signaling
Volume12
Issue number3
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

Fingerprint

Cytokines
Chemical activation
TNF Receptor-Associated Factor 6
Interleukin-33
Phosphorylation
Protein Transport
Atopic Dermatitis
Regulator Genes
Endothelial cells
Catalysis
Phosphatidylinositol 3-Kinases
Interleukin-1
Ulcerative Colitis
Gene expression
Rheumatoid Arthritis
Chronic Disease
Asthma
Endothelial Cells
Epithelial Cells
Proteins

Keywords

  • Immune response
  • Inflammation
  • NetSlim
  • Post-translational modifications
  • Pro-inflammatory cytokine
  • Protein-protein interactions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Pinto, S. M., Subbannayya, Y., Rex, D. A. B., Raju, R., Chatterjee, O., Advani, J., ... Pandey, A. (2018). A network map of IL-33 signaling pathway. Journal of Cell Communication and Signaling, 12(3), 615-624. https://doi.org/10.1007/s12079-018-0464-4

A network map of IL-33 signaling pathway. / Pinto, Sneha M.; Subbannayya, Yashwanth; Rex, D. A.B.; Raju, Rajesh; Chatterjee, Oishi; Advani, Jayshree; Radhakrishnan, Aneesha; Keshava Prasad, T. S.; Wani, Mohan R.; Pandey, Akhilesh.

In: Journal of Cell Communication and Signaling, Vol. 12, No. 3, 01.09.2018, p. 615-624.

Research output: Contribution to journalArticle

Pinto, SM, Subbannayya, Y, Rex, DAB, Raju, R, Chatterjee, O, Advani, J, Radhakrishnan, A, Keshava Prasad, TS, Wani, MR & Pandey, A 2018, 'A network map of IL-33 signaling pathway', Journal of Cell Communication and Signaling, vol. 12, no. 3, pp. 615-624. https://doi.org/10.1007/s12079-018-0464-4
Pinto SM, Subbannayya Y, Rex DAB, Raju R, Chatterjee O, Advani J et al. A network map of IL-33 signaling pathway. Journal of Cell Communication and Signaling. 2018 Sep 1;12(3):615-624. https://doi.org/10.1007/s12079-018-0464-4
Pinto, Sneha M. ; Subbannayya, Yashwanth ; Rex, D. A.B. ; Raju, Rajesh ; Chatterjee, Oishi ; Advani, Jayshree ; Radhakrishnan, Aneesha ; Keshava Prasad, T. S. ; Wani, Mohan R. ; Pandey, Akhilesh. / A network map of IL-33 signaling pathway. In: Journal of Cell Communication and Signaling. 2018 ; Vol. 12, No. 3. pp. 615-624.
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AU - Radhakrishnan, Aneesha

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