A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

Kursat Altinbas, Aysegul Ozerdem, Miguel L. Prieto, Manuel E. Fuentes, Nefize Yalin, Zeliha Ersoy, Omer Aydemir, Danilo Quiroz, Signem Oztekin, Jennifer R. Geske, Scott E. Feeder, Jules Angst, Mark A Frye

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.

Original languageEnglish (US)
Pages (from-to)478-482
Number of pages5
JournalJournal of Affective Disorders
Volume152-154
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Checklist
Bipolar Disorder
Depression
Libido
Depressive Disorder
Risk-Taking
Caffeine
Diagnostic and Statistical Manual of Mental Disorders
Sample Size
Interviews
Research

Keywords

  • Bipolar
  • Depression
  • Modified hypomania checklist
  • Unipolar

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression. / Altinbas, Kursat; Ozerdem, Aysegul; Prieto, Miguel L.; Fuentes, Manuel E.; Yalin, Nefize; Ersoy, Zeliha; Aydemir, Omer; Quiroz, Danilo; Oztekin, Signem; Geske, Jennifer R.; Feeder, Scott E.; Angst, Jules; Frye, Mark A.

In: Journal of Affective Disorders, Vol. 152-154, No. 1, 01.2014, p. 478-482.

Research output: Contribution to journalArticle

Altinbas, K, Ozerdem, A, Prieto, ML, Fuentes, ME, Yalin, N, Ersoy, Z, Aydemir, O, Quiroz, D, Oztekin, S, Geske, JR, Feeder, SE, Angst, J & Frye, MA 2014, 'A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression', Journal of Affective Disorders, vol. 152-154, no. 1, pp. 478-482. https://doi.org/10.1016/j.jad.2013.07.032
Altinbas, Kursat ; Ozerdem, Aysegul ; Prieto, Miguel L. ; Fuentes, Manuel E. ; Yalin, Nefize ; Ersoy, Zeliha ; Aydemir, Omer ; Quiroz, Danilo ; Oztekin, Signem ; Geske, Jennifer R. ; Feeder, Scott E. ; Angst, Jules ; Frye, Mark A. / A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression. In: Journal of Affective Disorders. 2014 ; Vol. 152-154, No. 1. pp. 478-482.
@article{07aeb8abfe484e4a988d3dec123f9cb6,
title = "A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression",
abstract = "Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.",
keywords = "Bipolar, Depression, Modified hypomania checklist, Unipolar",
author = "Kursat Altinbas and Aysegul Ozerdem and Prieto, {Miguel L.} and Fuentes, {Manuel E.} and Nefize Yalin and Zeliha Ersoy and Omer Aydemir and Danilo Quiroz and Signem Oztekin and Geske, {Jennifer R.} and Feeder, {Scott E.} and Jules Angst and Frye, {Mark A}",
year = "2014",
month = "1",
doi = "10.1016/j.jad.2013.07.032",
language = "English (US)",
volume = "152-154",
pages = "478--482",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

AU - Altinbas, Kursat

AU - Ozerdem, Aysegul

AU - Prieto, Miguel L.

AU - Fuentes, Manuel E.

AU - Yalin, Nefize

AU - Ersoy, Zeliha

AU - Aydemir, Omer

AU - Quiroz, Danilo

AU - Oztekin, Signem

AU - Geske, Jennifer R.

AU - Feeder, Scott E.

AU - Angst, Jules

AU - Frye, Mark A

PY - 2014/1

Y1 - 2014/1

N2 - Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.

AB - Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.

KW - Bipolar

KW - Depression

KW - Modified hypomania checklist

KW - Unipolar

UR - http://www.scopus.com/inward/record.url?scp=84889100550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889100550&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2013.07.032

DO - 10.1016/j.jad.2013.07.032

M3 - Article

C2 - 24070907

AN - SCOPUS:84889100550

VL - 152-154

SP - 478

EP - 482

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1

ER -