A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps

Katharina Glatz, Bobbi Pritt, Dieter Glatz, Arndt Hartmann, Michael J. O'Brien, Hagen Blaszyk

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

This Internet-based quiz (http://kathrin.unibas.ch/polyp/) ested the diagnostic variability of 168 pathologists in the diagnosis of 20 colorectal polyps on 3 representative images, including hyperplastic polyps (HPs), traditional serrated adenomas (TSAs), sessile serrated adenomas (SSAs), and tubulovillous adenomas (TVAs). Interobserver variability for each of the 20 lesions was significant and was most pronounced for SSAs. Correct answers were independent of the participant's experience with TVAs, HPs, and TSAs. Participants with gastrointestinal subspecialty training and those who had read a reference article on serrated polyps gave a significantly higher percentage of correct answers for SSAs. The nomenclature used for serrated polyps was generally inconsistent. Our results suggest significant shortcomings in the routine H&E diagnosis of serrated colorectal polyps. A diagnostically unifying concept for lesions of the serrated neoplasia pathway, standardization of nomenclature, training of pathologists, and possibly development of ancillary techniques are of paramount importance for accurate patient management.

Original languageEnglish (US)
Pages (from-to)938-945
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume127
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Polyps
Adenoma
Internet
Terminology
Observer Variation
Neoplasms

Keywords

  • Colon
  • Internet
  • Observer variability
  • Serrated polyps

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. / Glatz, Katharina; Pritt, Bobbi; Glatz, Dieter; Hartmann, Arndt; O'Brien, Michael J.; Blaszyk, Hagen.

In: American Journal of Clinical Pathology, Vol. 127, No. 6, 06.2007, p. 938-945.

Research output: Contribution to journalArticle

Glatz, Katharina ; Pritt, Bobbi ; Glatz, Dieter ; Hartmann, Arndt ; O'Brien, Michael J. ; Blaszyk, Hagen. / A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. In: American Journal of Clinical Pathology. 2007 ; Vol. 127, No. 6. pp. 938-945.
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