A Multifaceted Intervention for Patients With Anaphylaxis Increases Epinephrine Use in Adult Emergency Department

Veena Manivannan, Erik P. Hess, Venkatesh Bellamkonda, David M. Nestler, Fernanda Bellolio, John B. Hagan, Kharmene L. Sunga, Wyatt W. Decker, James T C Li, Lori N. Scanlan-Hanson, Samuel C. Vukov, Ronna L. Campbell

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Studies have documented inconsistent emergency anaphylaxis care and low compliance with published guidelines. Objective: To evaluate anaphylaxis management before and after implementation of an emergency department (ED) anaphylaxis order set and introduction of epinephrine autoinjectors, and to measure the effect on anaphylaxis guideline adherence. Methods: A cohort study was conducted from April 29, 2008, to August 9, 2012. Adult patients in the ED who were diagnosed with anaphylaxis were included. ED management, disposition, self-injectable epinephrine prescriptions, allergy follow-up, and incidence of biphasic reactions were evaluated. Results: The study included 202 patients. The median age of the patients was 45.3 years (interquartile range, 31.3-56.4 years); 139 (69%) were women. Patients who presented after order set implementation were more likely to be treated with epinephrine (51% vs 33%; odds ratio [OR] 2.05 [95% CI, 1.04-4.04]) and admitted to the ED observation unit (65% vs 44%; OR 2.38 [95% CI, 1.23-4.60]), and less likely to be dismissed home directly from ED (16% vs 29%, OR 0.47 [95% CI, 0.22-1.00]). Eleven patients (5%) had a biphasic reaction. Of these, 5 (46%) had the biphasic reaction in the ED observation unit; 1 patient was admitted to the intensive care unit. Six patients (55%) had reactions within 6 hours of initial symptom resolution, of whom 2 were admitted to the intensive care unit. Conclusions: Significantly higher proportions of patients with anaphylaxis received epinephrine and were admitted to the ED observation unit after introduction of epinephrine autoinjectors and order set implementation. Slightly more than half of the biphasic reactions occurred within the recommended observation time of 4 to 6 hours. Analysis of these data suggests that the multifaceted approach to changing anaphylaxis management described here improved guideline adherence.

Original languageEnglish (US)
Pages (from-to)294-299
Number of pages6
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume2
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Anaphylaxis
Epinephrine
Hospital Emergency Service
Observation
Guideline Adherence
Odds Ratio
Intensive Care Units
Emergency Medical Services
Prescriptions
Hypersensitivity
Cohort Studies
Guidelines
Injections
Incidence

Keywords

  • Anaphylaxis
  • Clinical decision support
  • Emergency department
  • Order set
  • Self-injectable epinephrine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Medicine(all)

Cite this

A Multifaceted Intervention for Patients With Anaphylaxis Increases Epinephrine Use in Adult Emergency Department. / Manivannan, Veena; Hess, Erik P.; Bellamkonda, Venkatesh; Nestler, David M.; Bellolio, Fernanda; Hagan, John B.; Sunga, Kharmene L.; Decker, Wyatt W.; Li, James T C; Scanlan-Hanson, Lori N.; Vukov, Samuel C.; Campbell, Ronna L.

In: Journal of Allergy and Clinical Immunology: In Practice, Vol. 2, No. 3, 2014, p. 294-299.

Research output: Contribution to journalArticle

Manivannan, V, Hess, EP, Bellamkonda, V, Nestler, DM, Bellolio, F, Hagan, JB, Sunga, KL, Decker, WW, Li, JTC, Scanlan-Hanson, LN, Vukov, SC & Campbell, RL 2014, 'A Multifaceted Intervention for Patients With Anaphylaxis Increases Epinephrine Use in Adult Emergency Department', Journal of Allergy and Clinical Immunology: In Practice, vol. 2, no. 3, pp. 294-299. https://doi.org/10.1016/j.jaip.2013.11.009
Manivannan, Veena ; Hess, Erik P. ; Bellamkonda, Venkatesh ; Nestler, David M. ; Bellolio, Fernanda ; Hagan, John B. ; Sunga, Kharmene L. ; Decker, Wyatt W. ; Li, James T C ; Scanlan-Hanson, Lori N. ; Vukov, Samuel C. ; Campbell, Ronna L. / A Multifaceted Intervention for Patients With Anaphylaxis Increases Epinephrine Use in Adult Emergency Department. In: Journal of Allergy and Clinical Immunology: In Practice. 2014 ; Vol. 2, No. 3. pp. 294-299.
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AU - Nestler, David M.

AU - Bellolio, Fernanda

AU - Hagan, John B.

AU - Sunga, Kharmene L.

AU - Decker, Wyatt W.

AU - Li, James T C

AU - Scanlan-Hanson, Lori N.

AU - Vukov, Samuel C.

AU - Campbell, Ronna L.

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N2 - Background: Studies have documented inconsistent emergency anaphylaxis care and low compliance with published guidelines. Objective: To evaluate anaphylaxis management before and after implementation of an emergency department (ED) anaphylaxis order set and introduction of epinephrine autoinjectors, and to measure the effect on anaphylaxis guideline adherence. Methods: A cohort study was conducted from April 29, 2008, to August 9, 2012. Adult patients in the ED who were diagnosed with anaphylaxis were included. ED management, disposition, self-injectable epinephrine prescriptions, allergy follow-up, and incidence of biphasic reactions were evaluated. Results: The study included 202 patients. The median age of the patients was 45.3 years (interquartile range, 31.3-56.4 years); 139 (69%) were women. Patients who presented after order set implementation were more likely to be treated with epinephrine (51% vs 33%; odds ratio [OR] 2.05 [95% CI, 1.04-4.04]) and admitted to the ED observation unit (65% vs 44%; OR 2.38 [95% CI, 1.23-4.60]), and less likely to be dismissed home directly from ED (16% vs 29%, OR 0.47 [95% CI, 0.22-1.00]). Eleven patients (5%) had a biphasic reaction. Of these, 5 (46%) had the biphasic reaction in the ED observation unit; 1 patient was admitted to the intensive care unit. Six patients (55%) had reactions within 6 hours of initial symptom resolution, of whom 2 were admitted to the intensive care unit. Conclusions: Significantly higher proportions of patients with anaphylaxis received epinephrine and were admitted to the ED observation unit after introduction of epinephrine autoinjectors and order set implementation. Slightly more than half of the biphasic reactions occurred within the recommended observation time of 4 to 6 hours. Analysis of these data suggests that the multifaceted approach to changing anaphylaxis management described here improved guideline adherence.

AB - Background: Studies have documented inconsistent emergency anaphylaxis care and low compliance with published guidelines. Objective: To evaluate anaphylaxis management before and after implementation of an emergency department (ED) anaphylaxis order set and introduction of epinephrine autoinjectors, and to measure the effect on anaphylaxis guideline adherence. Methods: A cohort study was conducted from April 29, 2008, to August 9, 2012. Adult patients in the ED who were diagnosed with anaphylaxis were included. ED management, disposition, self-injectable epinephrine prescriptions, allergy follow-up, and incidence of biphasic reactions were evaluated. Results: The study included 202 patients. The median age of the patients was 45.3 years (interquartile range, 31.3-56.4 years); 139 (69%) were women. Patients who presented after order set implementation were more likely to be treated with epinephrine (51% vs 33%; odds ratio [OR] 2.05 [95% CI, 1.04-4.04]) and admitted to the ED observation unit (65% vs 44%; OR 2.38 [95% CI, 1.23-4.60]), and less likely to be dismissed home directly from ED (16% vs 29%, OR 0.47 [95% CI, 0.22-1.00]). Eleven patients (5%) had a biphasic reaction. Of these, 5 (46%) had the biphasic reaction in the ED observation unit; 1 patient was admitted to the intensive care unit. Six patients (55%) had reactions within 6 hours of initial symptom resolution, of whom 2 were admitted to the intensive care unit. Conclusions: Significantly higher proportions of patients with anaphylaxis received epinephrine and were admitted to the ED observation unit after introduction of epinephrine autoinjectors and order set implementation. Slightly more than half of the biphasic reactions occurred within the recommended observation time of 4 to 6 hours. Analysis of these data suggests that the multifaceted approach to changing anaphylaxis management described here improved guideline adherence.

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KW - Clinical decision support

KW - Emergency department

KW - Order set

KW - Self-injectable epinephrine

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