A multidisciplinary approach to the management of breast cancer, part 2: Therapeutic considerations

Sandhya Pruthi, Judy C Boughey, Kathleen R Brandt, Amy C Degnim, Grace K. Dy, Matthew Philip Goetz, Edith A. Perez, Carol A. Reynolds, Paula J. Schomberg, James N. Ingle

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

New approaches to breast cancer treatment have enhanced clinical outcomes and patient care. These approaches include advances in breast irradiation and hormonal and systemic adjuvant therapies. In addition to the identification of new drug targets and targeted therapeutics (eg, trastuzumab), there is renewed reemphasis in the development of biomarkers for the prediction of response to therapy. One example is the pharmacogenetics of tamoxifen metabolism and the individualization of hormonal therapy. The current treatment of breast cancer continues to evolve rapidly, with new scientific and clinical achievements constantly changing the standard of care and leading to substantial reductions in breast cancer mortality. The goal of this article is to provide clinicians who care for women with breast cancer a multidisciplinary, state-of-the art approach to the treatment of these patients.

Original languageEnglish (US)
Pages (from-to)1131-1140
Number of pages10
JournalMayo Clinic Proceedings
Volume82
Issue number9
DOIs
StatePublished - 2007

Fingerprint

Breast Neoplasms
Therapeutics
Pharmacogenetics
Tamoxifen
Standard of Care
Patient Care
Breast
Biomarkers
Mortality
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A multidisciplinary approach to the management of breast cancer, part 2 : Therapeutic considerations. / Pruthi, Sandhya; Boughey, Judy C; Brandt, Kathleen R; Degnim, Amy C; Dy, Grace K.; Goetz, Matthew Philip; Perez, Edith A.; Reynolds, Carol A.; Schomberg, Paula J.; Ingle, James N.

In: Mayo Clinic Proceedings, Vol. 82, No. 9, 2007, p. 1131-1140.

Research output: Contribution to journalArticle

@article{24cb2eb94e314980a12a43acf1f0ee0b,
title = "A multidisciplinary approach to the management of breast cancer, part 2: Therapeutic considerations",
abstract = "New approaches to breast cancer treatment have enhanced clinical outcomes and patient care. These approaches include advances in breast irradiation and hormonal and systemic adjuvant therapies. In addition to the identification of new drug targets and targeted therapeutics (eg, trastuzumab), there is renewed reemphasis in the development of biomarkers for the prediction of response to therapy. One example is the pharmacogenetics of tamoxifen metabolism and the individualization of hormonal therapy. The current treatment of breast cancer continues to evolve rapidly, with new scientific and clinical achievements constantly changing the standard of care and leading to substantial reductions in breast cancer mortality. The goal of this article is to provide clinicians who care for women with breast cancer a multidisciplinary, state-of-the art approach to the treatment of these patients.",
author = "Sandhya Pruthi and Boughey, {Judy C} and Brandt, {Kathleen R} and Degnim, {Amy C} and Dy, {Grace K.} and Goetz, {Matthew Philip} and Perez, {Edith A.} and Reynolds, {Carol A.} and Schomberg, {Paula J.} and Ingle, {James N.}",
year = "2007",
doi = "10.4065/82.9.1131",
language = "English (US)",
volume = "82",
pages = "1131--1140",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "9",

}

TY - JOUR

T1 - A multidisciplinary approach to the management of breast cancer, part 2

T2 - Therapeutic considerations

AU - Pruthi, Sandhya

AU - Boughey, Judy C

AU - Brandt, Kathleen R

AU - Degnim, Amy C

AU - Dy, Grace K.

AU - Goetz, Matthew Philip

AU - Perez, Edith A.

AU - Reynolds, Carol A.

AU - Schomberg, Paula J.

AU - Ingle, James N.

PY - 2007

Y1 - 2007

N2 - New approaches to breast cancer treatment have enhanced clinical outcomes and patient care. These approaches include advances in breast irradiation and hormonal and systemic adjuvant therapies. In addition to the identification of new drug targets and targeted therapeutics (eg, trastuzumab), there is renewed reemphasis in the development of biomarkers for the prediction of response to therapy. One example is the pharmacogenetics of tamoxifen metabolism and the individualization of hormonal therapy. The current treatment of breast cancer continues to evolve rapidly, with new scientific and clinical achievements constantly changing the standard of care and leading to substantial reductions in breast cancer mortality. The goal of this article is to provide clinicians who care for women with breast cancer a multidisciplinary, state-of-the art approach to the treatment of these patients.

AB - New approaches to breast cancer treatment have enhanced clinical outcomes and patient care. These approaches include advances in breast irradiation and hormonal and systemic adjuvant therapies. In addition to the identification of new drug targets and targeted therapeutics (eg, trastuzumab), there is renewed reemphasis in the development of biomarkers for the prediction of response to therapy. One example is the pharmacogenetics of tamoxifen metabolism and the individualization of hormonal therapy. The current treatment of breast cancer continues to evolve rapidly, with new scientific and clinical achievements constantly changing the standard of care and leading to substantial reductions in breast cancer mortality. The goal of this article is to provide clinicians who care for women with breast cancer a multidisciplinary, state-of-the art approach to the treatment of these patients.

UR - http://www.scopus.com/inward/record.url?scp=34548412514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548412514&partnerID=8YFLogxK

U2 - 10.4065/82.9.1131

DO - 10.4065/82.9.1131

M3 - Article

C2 - 17803883

AN - SCOPUS:34548412514

VL - 82

SP - 1131

EP - 1140

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 9

ER -