TY - JOUR
T1 - A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis
T2 - The VENOST Study
AU - VENOST Study Group
AU - Colakoglu, Sena
AU - Duman, Taskin
AU - Tüfekci, Ahmet
AU - Bakar, Mustafa
AU - Nazliel, Bijen
AU - Caglayan, Hale Zeynep Batur
AU - Tascilar, Nida
AU - Acıkgoz, Mustafa
AU - Goksan, Baki
AU - Ince, Birsen
AU - Zeydan, Burcu
AU - Uluduz, Derya
AU - Kozak, Hasan Huseyin
AU - Demir, Serkan
AU - Senol, Mehmet Guney
AU - Ozdag, Fatih
AU - Tekeli, Hakan
AU - Misirli, Cemile Handan
AU - Kucukoglu, Hayriye
AU - Baybas, Sevim
AU - Cinar, Nilgun
AU - Domac, Fusun Mayda
AU - Ozturk, Serefnur
AU - Ekmekci, Hakan
AU - Yayla, Vildan
AU - Cabalar, Murat
AU - Karahan, Ali Yavuz
AU - Afsar, Nazire
AU - Ozaydin Goksu, Eylem
AU - Ucan Tokuc, Firdevs Ezgi
AU - Mengulluoglu, Necdet
AU - Aytac, Emrah
AU - Yesilot, Nilufer
AU - Yalin, Özgur Osman
AU - Oruc, Serdar
AU - Yaman, Mehmet
AU - Demirci, Seden
AU - Yurekli, Vedat Ali
AU - Yilmaz, Arda
AU - Genc, Hamit
AU - Gokce, Mustafa
AU - Utku, Uygar
AU - Kuspeci, Özge Yilmaz
AU - Uzuner, Gulnur
AU - Uzuner, Nevzat
AU - Midi, Ipek
AU - Bektas, Hesna
AU - Kablan, Yuksel
AU - Goksel, Basak K.
AU - Milanlioglu, Aysel
N1 - Publisher Copyright:
© 2017 National Stroke Association
PY - 2017/8
Y1 - 2017/8
N2 - Background Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. Methods All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. Results Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. Conclusions Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome.
AB - Background Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. Methods All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. Results Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. Conclusions Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome.
KW - Cerebrovascular disease
KW - cerebral venous sinus thrombosis
KW - clinic
KW - imaging
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UR - http://www.scopus.com/inward/citedby.url?scp=85020109081&partnerID=8YFLogxK
U2 - 10.1016/j.jstrokecerebrovasdis.2017.04.020
DO - 10.1016/j.jstrokecerebrovasdis.2017.04.020
M3 - Article
C2 - 28583818
AN - SCOPUS:85020109081
SN - 1052-3057
VL - 26
SP - 1848
EP - 1857
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 8
ER -