A multi-center study to improve understanding of pulmonary vascular disease through phenomics

Anna R. Hemnes; Gerald J. Beck; John H. Newman; Aiden Abidov; Micheala A. Aldred; John Barnard; Erika Berman Rosenzweig; Barry A. Borlaug; Wendy K. Chung; Suzy A.A. Comhair; Serpil C. Erzurum; Robert P. Frantz; Michael P. Gray; Gabriele Grunig; Paul M. Hassoun; Nicholas S. Hill; Evelyn M. Horn; Bo Hu; Jason K. Lempel; Bradley A. Maron; Stephen C. Mathai; Mitchell A. Olman; Franz P. Rischard; David M. Systrom; W. H.Wilson Tang; Aaron B. Waxman; Lei Xiao; Jason X.J. Yuan; Jane A. Leopold

doi:10.1161/CIRCRESAHA.117.311737

A multi-center study to improve understanding of pulmonary vascular disease through phenomics

Anna R. Hemnes, Gerald J. Beck, John H. Newman, Aiden Abidov, Micheala A. Aldred, John Barnard, Erika Berman Rosenzweig, Barry A. Borlaug, Wendy K. Chung, Suzy A.A. Comhair, Serpil C. Erzurum, Robert P. Frantz, Michael P. Gray, Gabriele Grunig, Paul M. Hassoun, Nicholas S. Hill, Evelyn M. Horn, Bo Hu, Jason K. Lempel, Bradley A. MaronStephen C. Mathai, Mitchell A. Olman, Franz P. Rischard, David M. Systrom, W. H.Wilson Tang, Aaron B. Waxman, Lei Xiao, Jason X.J. Yuan, Jane A. Leopold

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The National Institutes of Health (NIH)/National Heart, Lung and Blood institute (NHLBI) launched an initiative, PVDOMICS (Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics) that aims to augment the current pulmonary hypertension (PH) classification based on shared biological features. PVDOMICS will enroll 1500 participants with PH and disease and healthy comparators. Enrollees will undergo deep clinical phenotyping, and blood will be acquired for comprehensive omic analyses that will focus on discovery of molecular-based subtypes of pulmonary vascular disease (PVD) through application of high dimensional model-based clustering methods. In addition to an updated, molecular classification of PVD, the phenomic data generated will be a rich resource to the broad community of heart and lung disease investigators.

Original language	English (US)
Pages (from-to)	1136-1139
Number of pages	4
Journal	Circulation research
Volume	121
Issue number	10
DOIs	https://doi.org/10.1161/CIRCRESAHA.117.311737
State	Published - 2017

Keywords

Blood Institute (U.S.)
Diagnosis
Hypertension
Lung
National Heart
National Institutes of Health (U.S.)
Pulmonary
Pulmonary artery

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/CIRCRESAHA.117.311737

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Hemnes, A. R., Beck, G. J., Newman, J. H., Abidov, A., Aldred, M. A., Barnard, J., Rosenzweig, E. B., Borlaug, B. A., Chung, W. K., Comhair, S. A. A., Erzurum, S. C., Frantz, R. P., Gray, M. P., Grunig, G., Hassoun, P. M., Hill, N. S., Horn, E. M., Hu, B., Lempel, J. K., ... Leopold, J. A. (2017). A multi-center study to improve understanding of pulmonary vascular disease through phenomics. Circulation research, 121(10), 1136-1139. https://doi.org/10.1161/CIRCRESAHA.117.311737

Hemnes, AR, Beck, GJ, Newman, JH, Abidov, A, Aldred, MA, Barnard, J, Rosenzweig, EB, Borlaug, BA, Chung, WK, Comhair, SAA, Erzurum, SC, Frantz, RP, Gray, MP, Grunig, G, Hassoun, PM, Hill, NS, Horn, EM, Hu, B, Lempel, JK, Maron, BA, Mathai, SC, Olman, MA, Rischard, FP, Systrom, DM, Tang, WHW, Waxman, AB, Xiao, L, Yuan, JXJ & Leopold, JA 2017, 'A multi-center study to improve understanding of pulmonary vascular disease through phenomics', Circulation research, vol. 121, no. 10, pp. 1136-1139. https://doi.org/10.1161/CIRCRESAHA.117.311737

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abstract = "The National Institutes of Health (NIH)/National Heart, Lung and Blood institute (NHLBI) launched an initiative, PVDOMICS (Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics) that aims to augment the current pulmonary hypertension (PH) classification based on shared biological features. PVDOMICS will enroll 1500 participants with PH and disease and healthy comparators. Enrollees will undergo deep clinical phenotyping, and blood will be acquired for comprehensive omic analyses that will focus on discovery of molecular-based subtypes of pulmonary vascular disease (PVD) through application of high dimensional model-based clustering methods. In addition to an updated, molecular classification of PVD, the phenomic data generated will be a rich resource to the broad community of heart and lung disease investigators.",

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author = "Hemnes, {Anna R.} and Beck, {Gerald J.} and Newman, {John H.} and Aiden Abidov and Aldred, {Micheala A.} and John Barnard and Rosenzweig, {Erika Berman} and Borlaug, {Barry A.} and Chung, {Wendy K.} and Comhair, {Suzy A.A.} and Erzurum, {Serpil C.} and Frantz, {Robert P.} and Gray, {Michael P.} and Gabriele Grunig and Hassoun, {Paul M.} and Hill, {Nicholas S.} and Horn, {Evelyn M.} and Bo Hu and Lempel, {Jason K.} and Maron, {Bradley A.} and Mathai, {Stephen C.} and Olman, {Mitchell A.} and Rischard, {Franz P.} and Systrom, {David M.} and Tang, {W. H.Wilson} and Waxman, {Aaron B.} and Lei Xiao and Yuan, {Jason X.J.} and Leopold, {Jane A.}",

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year = "2017",

doi = "10.1161/CIRCRESAHA.117.311737",

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AU - Beck, Gerald J.

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AU - Aldred, Micheala A.

AU - Barnard, John

AU - Rosenzweig, Erika Berman

AU - Borlaug, Barry A.

AU - Chung, Wendy K.

AU - Comhair, Suzy A.A.

AU - Erzurum, Serpil C.

AU - Frantz, Robert P.

AU - Gray, Michael P.

AU - Grunig, Gabriele

AU - Hassoun, Paul M.

AU - Hill, Nicholas S.

AU - Horn, Evelyn M.

AU - Hu, Bo

AU - Lempel, Jason K.

AU - Maron, Bradley A.

AU - Mathai, Stephen C.

AU - Olman, Mitchell A.

AU - Rischard, Franz P.

AU - Systrom, David M.

AU - Tang, W. H.Wilson

AU - Waxman, Aaron B.

AU - Xiao, Lei

AU - Yuan, Jason X.J.

AU - Leopold, Jane A.

PY - 2017

Y1 - 2017

N2 - The National Institutes of Health (NIH)/National Heart, Lung and Blood institute (NHLBI) launched an initiative, PVDOMICS (Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics) that aims to augment the current pulmonary hypertension (PH) classification based on shared biological features. PVDOMICS will enroll 1500 participants with PH and disease and healthy comparators. Enrollees will undergo deep clinical phenotyping, and blood will be acquired for comprehensive omic analyses that will focus on discovery of molecular-based subtypes of pulmonary vascular disease (PVD) through application of high dimensional model-based clustering methods. In addition to an updated, molecular classification of PVD, the phenomic data generated will be a rich resource to the broad community of heart and lung disease investigators.

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KW - Blood Institute (U.S.)

KW - Diagnosis

KW - Hypertension

KW - Lung

KW - National Heart

KW - National Institutes of Health (U.S.)

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KW - Pulmonary artery

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A multi-center study to improve understanding of pulmonary vascular disease through phenomics

Abstract

Keywords

ASJC Scopus subject areas

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