A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration

Dennis W Dickson, H. Ksiezak-Reding, P. Davies, S. H. Yen

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggests that granulovacuolar degeneration may contain phosphorylated proteins, possibly due to autophagy of phosphorylated perikaryal proteins that appear to be increased in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)254-258
Number of pages5
JournalActa Neuropathologica
Volume73
Issue number3
DOIs
StatePublished - Sep 1987
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Granulovacuolar degeneration
  • Immunostaining
  • Monoclonal antibody

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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