A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration

Dennis W Dickson, H. Ksiezak-Reding, P. Davies, S. H. Yen

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggests that granulovacuolar degeneration may contain phosphorylated proteins, possibly due to autophagy of phosphorylated perikaryal proteins that appear to be increased in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)254-258
Number of pages5
JournalActa Neuropathologica
Volume73
Issue number3
DOIs
StatePublished - Sep 1987
Externally publishedYes

Fingerprint

Neurofilament Proteins
tau Proteins
Neurofibrillary Tangles
Epitopes
Monoclonal Antibodies
Autophagy
Amyloid Plaques
Neurites
Alzheimer Disease
Proteins
Brain
neurofilament protein H

Keywords

  • Alzheimer's disease
  • Granulovacuolar degeneration
  • Immunostaining
  • Monoclonal antibody

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration. / Dickson, Dennis W; Ksiezak-Reding, H.; Davies, P.; Yen, S. H.

In: Acta Neuropathologica, Vol. 73, No. 3, 09.1987, p. 254-258.

Research output: Contribution to journalArticle

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