Abstract
Background: Proteinase 3 is an abundant serine protease with high similarity to neutrophil elastase and a major autoimmune target in systemic vasculitis. Results: We identified a monoclonal antibody that inhibits PR3 activity. Conclusion: PR3-inhibiting antibodies can change its conformation and impair interactions with β1-proteinase inhibitor. Significance: PR3-inhibiting antibodies may play a role in autoimmune vasculitis and could be exploited as highly selective inhibitors.
Original language | English (US) |
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Pages (from-to) | 26635-26648 |
Number of pages | 14 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 37 |
DOIs | |
State | Published - Sep 13 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology