A model of glucose production during a meal

Chiara Dalla Man, Gianna Toffolo, Rita Basu, Robert A. Rizza, Claudio Cobelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

The efficiency of glucose and insulin control on glucose production (EGP) plays an important role in glucose homeostasis and its derangement in diabetes. Therefore the ability to accurately quantify indices of the individual role of glucose (GEL) and insulin (SI L) in the suppression of EGP would allow to improve the understanding of liver metabolism. Measuring these indices by minimal modelling of tracer labelled and unlabelled glucose data is often unreliable, possibly due to an inadequate description of EGP included in the minimal model (EGPMM). Moreover a validation of EGPMM on EGP data has never been done. Here EGPMM and alternative EGP descriptions were tested on recent model-independent EGP data of 20 subjects obtained with a triple-tracer meal protocol. Model performances were compared in terms of data fit and physiological plausibility. EGP MM was not able to describe EGP data, while one of the new model showed a good fit and provided accurate and precise estimates of hepatic sensitivity indices: GEL=0.013 ± 0.001 dl/kg/min; S I L =5.71 ± 0.48 10-4 dl/kg/min per μU/ml (36% and 41%, respectively, of total sensitivity indices GE TOT and SI TOT). This novel approach will allow to enhance our understanding of the role of the liver in pathophysiological states.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages5647-5650
Number of pages4
DOIs
StatePublished - 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

Fingerprint

Glucose
Insulin
Liver
Medical problems
Metabolism

ASJC Scopus subject areas

  • Bioengineering

Cite this

Dalla Man, C., Toffolo, G., Basu, R., Rizza, R. A., & Cobelli, C. (2006). A model of glucose production during a meal. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 5647-5650). [4029885] https://doi.org/10.1109/IEMBS.2006.260809

A model of glucose production during a meal. / Dalla Man, Chiara; Toffolo, Gianna; Basu, Rita; Rizza, Robert A.; Cobelli, Claudio.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 5647-5650 4029885.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dalla Man, C, Toffolo, G, Basu, R, Rizza, RA & Cobelli, C 2006, A model of glucose production during a meal. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4029885, pp. 5647-5650, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.260809
Dalla Man C, Toffolo G, Basu R, Rizza RA, Cobelli C. A model of glucose production during a meal. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 5647-5650. 4029885 https://doi.org/10.1109/IEMBS.2006.260809
Dalla Man, Chiara ; Toffolo, Gianna ; Basu, Rita ; Rizza, Robert A. ; Cobelli, Claudio. / A model of glucose production during a meal. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 5647-5650
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