A Mitochondrial Checkpoint in Autoimmune Disease

Cornelia M. Weyand, Jörg J. Goronzy

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

Cell-fate decisions in innate and adaptive immune cells are metabolically regulated and modified by tissue-derived signals, thereby balancing protective and pathogenic immunity. Reporting in Science, Ling et al. (2018) have identified C1q as a mitochondrial activator that suppresses exuberant anti-self and anti-viral CD8 T cell effector responses to prevent autoimmune disease. Cell-fate decisions in innate and adaptive immune cells are metabolically regulated and modified by tissue-derived signals, thereby balancing protective and pathogenic immunity. Reporting in Science, Ling et al. (2018) have identified C1q as a mitochondrial activator that suppresses exuberant anti-self and anti-viral CD8 T cell effector responses to prevent autoimmune disease.

Original languageEnglish (US)
Pages (from-to)185-186
Number of pages2
JournalCell Metabolism
Volume28
Issue number2
DOIs
StatePublished - Aug 7 2018

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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