A MICROFLUIDIC DEVICE FOR CULTURING INTACT LIVER TISSUE

Jose M. de Hoyos-Vega, Hye Jin Hong, Gulnaz Stybayeva, Alexander Revzin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hepatocytes are highly differentiated cells that lose phenotype and function after 3 to 5 days in vitro. It is well appreciated in the field that hepatic function may be rescued by introducing support cast cells (e.g. stromal cells) or components of extracellular matrix (ECM). In this study, we developed a microfluidic device for cultivating intact liver tissue that retains native cellular and matrix elements and demonstrated maintenance of high level of hepatic function for at least 7 days.

Original languageEnglish (US)
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages443-444
Number of pages2
ISBN (Electronic)9781733419031
StatePublished - 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
Duration: Oct 10 2021Oct 14 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs, Virtual
Period10/10/2110/14/21

Keywords

  • Ex vivo cultures
  • Hepatocytes
  • Microfluidics
  • Needle core biopsy

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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