A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program

Michael A. Province, Sharon L.R. Kardia, Koustubh Ranade, Dabeeru C. Rao, Bonnie A. Thiel, Richard S. Cooper, Neil Risch, Stephen T. Turner, David R. Cox, Steven C. Hunt, Alan B. Weder, Eric Boerwinkle

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension in all populations.

Original languageEnglish (US)
Pages (from-to)144-147
Number of pages4
JournalAmerican journal of hypertension
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Genome scan
  • Hypertension
  • Meta-analysis

ASJC Scopus subject areas

  • Internal Medicine

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    Province, M. A., Kardia, S. L. R., Ranade, K., Rao, D. C., Thiel, B. A., Cooper, R. S., Risch, N., Turner, S. T., Cox, D. R., Hunt, S. C., Weder, A. B., & Boerwinkle, E. (2003). A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program. American journal of hypertension, 16(2), 144-147. https://doi.org/10.1016/S0895-7061(02)03248-X