A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Ali Amin Al Olama, Zsofia Kote-Jarai, Fredrick R. Schumacher, Fredrik Wiklund, Sonja I. Berndt, Sara Benlloch, Graham G. Giles, Gianluca Severi, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, David J. Hunter, Brian E. Henderson, Michael J. Thun, Michael Gaziano, Edward L. Giovannucci, Afshan Siddiq, Ruth C. Travis, David G. Cox, Federico CanzianElio Riboli, Timothy J. Key, Gerald Andriole, Demetrius Albanes, Richard B. Hayes, Johanna Schleutker, Anssi Auvinen, Teuvo L J Tammela, Maren Weischer, Janet L. Stanford, Elaine A. Ostrander, Cezary Cybulski, Jan Lubinski, Stephen N Thibodeau, Daniel J Schaid, Karina D. Sorensen, Jyotsna Batra, Judith A. Clements, Suzanne Chambers, Joanne Aitken, Robert A. Gardiner, Christiane Maier, Walther Vogel, Thilo Dörk, Hermann Brenner, Tomonori Habuchi, Sue Ingles, Esther M. John, Joanne L. Dickinson, Lisa Cannon-Albright, Manuel R. Teixeira, Radka Kaneva, Hong Wei Zhang, Yong Jie Lu, Jong Y. Park, Kathleen A. Cooney, Kenneth R. Muir, Daniel A. Leongamornlert, Edward Saunders, Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Koveela Govindasami, Lynne T. O'Brien, Rosemary A. Wilkinson, Amanda L. Hall, Emma J. Sawyer, Tokhir Dadaev, Jonathan Morrison, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S. Cooper, Artitaya Lophatonanon, Melissa C. Southey, John L. Hopper, Dallas English, Jarmo Virtamo, Loic Le Marchand, Daniele Campa, Rudolf Kaaks, Sara Lindstrom, W. Ryan Diver, Susan Gapstur, Meredith Yeager, Angela Cox, Mariana C. Stern, Roman Corral, Markus Aly, William Isaacs, Jan Adolfsson, Jianfeng Xu, S. Lilly Zheng, Tiina Wahlfors, Kimmo Taari, Paula Kujala, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Ruth Frikke-Schmidt, Stig E. Bojesen, Liesel M. FitzGerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, Torben Falck Orntoft, Michael Borre, Antje Rinckleb, Manuel Luedeke, Kathleen Herkommer, Andreas Meyer, Jü rgen Serth, James R. Marthick, Briony Patterson, Dominika Wokolorczyk, Amanda Spurdle, Felicity Lose, Shannon K. McDonnell, Amit D. Joshi, Ahva Shahabi, Pedro Pinto, Joana Santos, Ana Ray, Thomas A. Sellers, Hui Yi Lin, Robert A. Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Norihiko Tsuchiya, Shintaro Narita, Guang Wen Cao, Chavdar Slavov, Vanio Mitev, Stephen Chanock, Henrik Gronberg, Christopher A. Haiman, Peter Kraft, Douglas F. Easton, Rosalind A. Eeles

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

Original languageEnglish (US)
Article numberdds425
Pages (from-to)408-415
Number of pages8
JournalHuman Molecular Genetics
Volume22
Issue number2
DOIs
StatePublished - Jan 2013

Fingerprint

Genome-Wide Association Study
Meta-Analysis
Prostatic Neoplasms
Chromosomes, Human, Pair 19
Single Nucleotide Polymorphism
Alleles
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

Al Olama, A. A., Kote-Jarai, Z., Schumacher, F. R., Wiklund, F., Berndt, S. I., Benlloch, S., ... Eeles, R. A. (2013). A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human Molecular Genetics, 22(2), 408-415. [dds425]. https://doi.org/10.1093/hmg/dds425

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. / Al Olama, Ali Amin; Kote-Jarai, Zsofia; Schumacher, Fredrick R.; Wiklund, Fredrik; Berndt, Sonja I.; Benlloch, Sara; Giles, Graham G.; Severi, Gianluca; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Hunter, David J.; Henderson, Brian E.; Thun, Michael J.; Gaziano, Michael; Giovannucci, Edward L.; Siddiq, Afshan; Travis, Ruth C.; Cox, David G.; Canzian, Federico; Riboli, Elio; Key, Timothy J.; Andriole, Gerald; Albanes, Demetrius; Hayes, Richard B.; Schleutker, Johanna; Auvinen, Anssi; Tammela, Teuvo L J; Weischer, Maren; Stanford, Janet L.; Ostrander, Elaine A.; Cybulski, Cezary; Lubinski, Jan; Thibodeau, Stephen N; Schaid, Daniel J; Sorensen, Karina D.; Batra, Jyotsna; Clements, Judith A.; Chambers, Suzanne; Aitken, Joanne; Gardiner, Robert A.; Maier, Christiane; Vogel, Walther; Dörk, Thilo; Brenner, Hermann; Habuchi, Tomonori; Ingles, Sue; John, Esther M.; Dickinson, Joanne L.; Cannon-Albright, Lisa; Teixeira, Manuel R.; Kaneva, Radka; Zhang, Hong Wei; Lu, Yong Jie; Park, Jong Y.; Cooney, Kathleen A.; Muir, Kenneth R.; Leongamornlert, Daniel A.; Saunders, Edward; Tymrakiewicz, Malgorzata; Mahmud, Nadiya; Guy, Michelle; Govindasami, Koveela; O'Brien, Lynne T.; Wilkinson, Rosemary A.; Hall, Amanda L.; Sawyer, Emma J.; Dadaev, Tokhir; Morrison, Jonathan; Dearnaley, David P.; Horwich, Alan; Huddart, Robert A.; Khoo, Vincent S.; Parker, Christopher C.; Van As, Nicholas; Woodhouse, Christopher J.; Thompson, Alan; Dudderidge, Tim; Ogden, Chris; Cooper, Colin S.; Lophatonanon, Artitaya; Southey, Melissa C.; Hopper, John L.; English, Dallas; Virtamo, Jarmo; Marchand, Loic Le; Campa, Daniele; Kaaks, Rudolf; Lindstrom, Sara; Diver, W. Ryan; Gapstur, Susan; Yeager, Meredith; Cox, Angela; Stern, Mariana C.; Corral, Roman; Aly, Markus; Isaacs, William; Adolfsson, Jan; Xu, Jianfeng; Zheng, S. Lilly; Wahlfors, Tiina; Taari, Kimmo; Kujala, Paula; Klarskov, Peter; Nordestgaard, Børge G.; Røder, M. Andreas; Frikke-Schmidt, Ruth; Bojesen, Stig E.; FitzGerald, Liesel M.; Kolb, Suzanne; Kwon, Erika M.; Karyadi, Danielle M.; Orntoft, Torben Falck; Borre, Michael; Rinckleb, Antje; Luedeke, Manuel; Herkommer, Kathleen; Meyer, Andreas; Serth, Jü rgen; Marthick, James R.; Patterson, Briony; Wokolorczyk, Dominika; Spurdle, Amanda; Lose, Felicity; McDonnell, Shannon K.; Joshi, Amit D.; Shahabi, Ahva; Pinto, Pedro; Santos, Joana; Ray, Ana; Sellers, Thomas A.; Lin, Hui Yi; Stephenson, Robert A.; Teerlink, Craig; Muller, Heiko; Rothenbacher, Dietrich; Tsuchiya, Norihiko; Narita, Shintaro; Cao, Guang Wen; Slavov, Chavdar; Mitev, Vanio; Chanock, Stephen; Gronberg, Henrik; Haiman, Christopher A.; Kraft, Peter; Easton, Douglas F.; Eeles, Rosalind A.

In: Human Molecular Genetics, Vol. 22, No. 2, dds425, 01.2013, p. 408-415.

Research output: Contribution to journalArticle

Al Olama, AA, Kote-Jarai, Z, Schumacher, FR, Wiklund, F, Berndt, SI, Benlloch, S, Giles, GG, Severi, G, Neal, DE, Hamdy, FC, Donovan, JL, Hunter, DJ, Henderson, BE, Thun, MJ, Gaziano, M, Giovannucci, EL, Siddiq, A, Travis, RC, Cox, DG, Canzian, F, Riboli, E, Key, TJ, Andriole, G, Albanes, D, Hayes, RB, Schleutker, J, Auvinen, A, Tammela, TLJ, Weischer, M, Stanford, JL, Ostrander, EA, Cybulski, C, Lubinski, J, Thibodeau, SN, Schaid, DJ, Sorensen, KD, Batra, J, Clements, JA, Chambers, S, Aitken, J, Gardiner, RA, Maier, C, Vogel, W, Dörk, T, Brenner, H, Habuchi, T, Ingles, S, John, EM, Dickinson, JL, Cannon-Albright, L, Teixeira, MR, Kaneva, R, Zhang, HW, Lu, YJ, Park, JY, Cooney, KA, Muir, KR, Leongamornlert, DA, Saunders, E, Tymrakiewicz, M, Mahmud, N, Guy, M, Govindasami, K, O'Brien, LT, Wilkinson, RA, Hall, AL, Sawyer, EJ, Dadaev, T, Morrison, J, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Dudderidge, T, Ogden, C, Cooper, CS, Lophatonanon, A, Southey, MC, Hopper, JL, English, D, Virtamo, J, Marchand, LL, Campa, D, Kaaks, R, Lindstrom, S, Diver, WR, Gapstur, S, Yeager, M, Cox, A, Stern, MC, Corral, R, Aly, M, Isaacs, W, Adolfsson, J, Xu, J, Zheng, SL, Wahlfors, T, Taari, K, Kujala, P, Klarskov, P, Nordestgaard, BG, Røder, MA, Frikke-Schmidt, R, Bojesen, SE, FitzGerald, LM, Kolb, S, Kwon, EM, Karyadi, DM, Orntoft, TF, Borre, M, Rinckleb, A, Luedeke, M, Herkommer, K, Meyer, A, Serth, JR, Marthick, JR, Patterson, B, Wokolorczyk, D, Spurdle, A, Lose, F, McDonnell, SK, Joshi, AD, Shahabi, A, Pinto, P, Santos, J, Ray, A, Sellers, TA, Lin, HY, Stephenson, RA, Teerlink, C, Muller, H, Rothenbacher, D, Tsuchiya, N, Narita, S, Cao, GW, Slavov, C, Mitev, V, Chanock, S, Gronberg, H, Haiman, CA, Kraft, P, Easton, DF & Eeles, RA 2013, 'A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease', Human Molecular Genetics, vol. 22, no. 2, dds425, pp. 408-415. https://doi.org/10.1093/hmg/dds425
Al Olama, Ali Amin ; Kote-Jarai, Zsofia ; Schumacher, Fredrick R. ; Wiklund, Fredrik ; Berndt, Sonja I. ; Benlloch, Sara ; Giles, Graham G. ; Severi, Gianluca ; Neal, David E. ; Hamdy, Freddie C. ; Donovan, Jenny L. ; Hunter, David J. ; Henderson, Brian E. ; Thun, Michael J. ; Gaziano, Michael ; Giovannucci, Edward L. ; Siddiq, Afshan ; Travis, Ruth C. ; Cox, David G. ; Canzian, Federico ; Riboli, Elio ; Key, Timothy J. ; Andriole, Gerald ; Albanes, Demetrius ; Hayes, Richard B. ; Schleutker, Johanna ; Auvinen, Anssi ; Tammela, Teuvo L J ; Weischer, Maren ; Stanford, Janet L. ; Ostrander, Elaine A. ; Cybulski, Cezary ; Lubinski, Jan ; Thibodeau, Stephen N ; Schaid, Daniel J ; Sorensen, Karina D. ; Batra, Jyotsna ; Clements, Judith A. ; Chambers, Suzanne ; Aitken, Joanne ; Gardiner, Robert A. ; Maier, Christiane ; Vogel, Walther ; Dörk, Thilo ; Brenner, Hermann ; Habuchi, Tomonori ; Ingles, Sue ; John, Esther M. ; Dickinson, Joanne L. ; Cannon-Albright, Lisa ; Teixeira, Manuel R. ; Kaneva, Radka ; Zhang, Hong Wei ; Lu, Yong Jie ; Park, Jong Y. ; Cooney, Kathleen A. ; Muir, Kenneth R. ; Leongamornlert, Daniel A. ; Saunders, Edward ; Tymrakiewicz, Malgorzata ; Mahmud, Nadiya ; Guy, Michelle ; Govindasami, Koveela ; O'Brien, Lynne T. ; Wilkinson, Rosemary A. ; Hall, Amanda L. ; Sawyer, Emma J. ; Dadaev, Tokhir ; Morrison, Jonathan ; Dearnaley, David P. ; Horwich, Alan ; Huddart, Robert A. ; Khoo, Vincent S. ; Parker, Christopher C. ; Van As, Nicholas ; Woodhouse, Christopher J. ; Thompson, Alan ; Dudderidge, Tim ; Ogden, Chris ; Cooper, Colin S. ; Lophatonanon, Artitaya ; Southey, Melissa C. ; Hopper, John L. ; English, Dallas ; Virtamo, Jarmo ; Marchand, Loic Le ; Campa, Daniele ; Kaaks, Rudolf ; Lindstrom, Sara ; Diver, W. Ryan ; Gapstur, Susan ; Yeager, Meredith ; Cox, Angela ; Stern, Mariana C. ; Corral, Roman ; Aly, Markus ; Isaacs, William ; Adolfsson, Jan ; Xu, Jianfeng ; Zheng, S. Lilly ; Wahlfors, Tiina ; Taari, Kimmo ; Kujala, Paula ; Klarskov, Peter ; Nordestgaard, Børge G. ; Røder, M. Andreas ; Frikke-Schmidt, Ruth ; Bojesen, Stig E. ; FitzGerald, Liesel M. ; Kolb, Suzanne ; Kwon, Erika M. ; Karyadi, Danielle M. ; Orntoft, Torben Falck ; Borre, Michael ; Rinckleb, Antje ; Luedeke, Manuel ; Herkommer, Kathleen ; Meyer, Andreas ; Serth, Jü rgen ; Marthick, James R. ; Patterson, Briony ; Wokolorczyk, Dominika ; Spurdle, Amanda ; Lose, Felicity ; McDonnell, Shannon K. ; Joshi, Amit D. ; Shahabi, Ahva ; Pinto, Pedro ; Santos, Joana ; Ray, Ana ; Sellers, Thomas A. ; Lin, Hui Yi ; Stephenson, Robert A. ; Teerlink, Craig ; Muller, Heiko ; Rothenbacher, Dietrich ; Tsuchiya, Norihiko ; Narita, Shintaro ; Cao, Guang Wen ; Slavov, Chavdar ; Mitev, Vanio ; Chanock, Stephen ; Gronberg, Henrik ; Haiman, Christopher A. ; Kraft, Peter ; Easton, Douglas F. ; Eeles, Rosalind A. / A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. In: Human Molecular Genetics. 2013 ; Vol. 22, No. 2. pp. 408-415.
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title = "A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease",
abstract = "Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95{\%} confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.",
author = "{Al Olama}, {Ali Amin} and Zsofia Kote-Jarai and Schumacher, {Fredrick R.} and Fredrik Wiklund and Berndt, {Sonja I.} and Sara Benlloch and Giles, {Graham G.} and Gianluca Severi and Neal, {David E.} and Hamdy, {Freddie C.} and Donovan, {Jenny L.} and Hunter, {David J.} and Henderson, {Brian E.} and Thun, {Michael J.} and Michael Gaziano and Giovannucci, {Edward L.} and Afshan Siddiq and Travis, {Ruth C.} and Cox, {David G.} and Federico Canzian and Elio Riboli and Key, {Timothy J.} and Gerald Andriole and Demetrius Albanes and Hayes, {Richard B.} and Johanna Schleutker and Anssi Auvinen and Tammela, {Teuvo L J} and Maren Weischer and Stanford, {Janet L.} and Ostrander, {Elaine A.} and Cezary Cybulski and Jan Lubinski and Thibodeau, {Stephen N} and Schaid, {Daniel J} and Sorensen, {Karina D.} and Jyotsna Batra and Clements, {Judith A.} and Suzanne Chambers and Joanne Aitken and Gardiner, {Robert A.} and Christiane Maier and Walther Vogel and Thilo D{\"o}rk and Hermann Brenner and Tomonori Habuchi and Sue Ingles and John, {Esther M.} and Dickinson, {Joanne L.} and Lisa Cannon-Albright and Teixeira, {Manuel R.} and Radka Kaneva and Zhang, {Hong Wei} and Lu, {Yong Jie} and Park, {Jong Y.} and Cooney, {Kathleen A.} and Muir, {Kenneth R.} and Leongamornlert, {Daniel A.} and Edward Saunders and Malgorzata Tymrakiewicz and Nadiya Mahmud and Michelle Guy and Koveela Govindasami and O'Brien, {Lynne T.} and Wilkinson, {Rosemary A.} and Hall, {Amanda L.} and Sawyer, {Emma J.} and Tokhir Dadaev and Jonathan Morrison and Dearnaley, {David P.} and Alan Horwich and Huddart, {Robert A.} and Khoo, {Vincent S.} and Parker, {Christopher C.} and {Van As}, Nicholas and Woodhouse, {Christopher J.} and Alan Thompson and Tim Dudderidge and Chris Ogden and Cooper, {Colin S.} and Artitaya Lophatonanon and Southey, {Melissa C.} and Hopper, {John L.} and Dallas English and Jarmo Virtamo and Marchand, {Loic Le} and Daniele Campa and Rudolf Kaaks and Sara Lindstrom and Diver, {W. Ryan} and Susan Gapstur and Meredith Yeager and Angela Cox and Stern, {Mariana C.} and Roman Corral and Markus Aly and William Isaacs and Jan Adolfsson and Jianfeng Xu and Zheng, {S. Lilly} and Tiina Wahlfors and Kimmo Taari and Paula Kujala and Peter Klarskov and Nordestgaard, {B{\o}rge G.} and R{\o}der, {M. Andreas} and Ruth Frikke-Schmidt and Bojesen, {Stig E.} and FitzGerald, {Liesel M.} and Suzanne Kolb and Kwon, {Erika M.} and Karyadi, {Danielle M.} and Orntoft, {Torben Falck} and Michael Borre and Antje Rinckleb and Manuel Luedeke and Kathleen Herkommer and Andreas Meyer and Serth, {J{\"u} rgen} and Marthick, {James R.} and Briony Patterson and Dominika Wokolorczyk and Amanda Spurdle and Felicity Lose and McDonnell, {Shannon K.} and Joshi, {Amit D.} and Ahva Shahabi and Pedro Pinto and Joana Santos and Ana Ray and Sellers, {Thomas A.} and Lin, {Hui Yi} and Stephenson, {Robert A.} and Craig Teerlink and Heiko Muller and Dietrich Rothenbacher and Norihiko Tsuchiya and Shintaro Narita and Cao, {Guang Wen} and Chavdar Slavov and Vanio Mitev and Stephen Chanock and Henrik Gronberg and Haiman, {Christopher A.} and Peter Kraft and Easton, {Douglas F.} and Eeles, {Rosalind A.}",
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month = "1",
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T1 - A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

AU - Al Olama, Ali Amin

AU - Kote-Jarai, Zsofia

AU - Schumacher, Fredrick R.

AU - Wiklund, Fredrik

AU - Berndt, Sonja I.

AU - Benlloch, Sara

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Neal, David E.

AU - Hamdy, Freddie C.

AU - Donovan, Jenny L.

AU - Hunter, David J.

AU - Henderson, Brian E.

AU - Thun, Michael J.

AU - Gaziano, Michael

AU - Giovannucci, Edward L.

AU - Siddiq, Afshan

AU - Travis, Ruth C.

AU - Cox, David G.

AU - Canzian, Federico

AU - Riboli, Elio

AU - Key, Timothy J.

AU - Andriole, Gerald

AU - Albanes, Demetrius

AU - Hayes, Richard B.

AU - Schleutker, Johanna

AU - Auvinen, Anssi

AU - Tammela, Teuvo L J

AU - Weischer, Maren

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Thibodeau, Stephen N

AU - Schaid, Daniel J

AU - Sorensen, Karina D.

AU - Batra, Jyotsna

AU - Clements, Judith A.

AU - Chambers, Suzanne

AU - Aitken, Joanne

AU - Gardiner, Robert A.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Dörk, Thilo

AU - Brenner, Hermann

AU - Habuchi, Tomonori

AU - Ingles, Sue

AU - John, Esther M.

AU - Dickinson, Joanne L.

AU - Cannon-Albright, Lisa

AU - Teixeira, Manuel R.

AU - Kaneva, Radka

AU - Zhang, Hong Wei

AU - Lu, Yong Jie

AU - Park, Jong Y.

AU - Cooney, Kathleen A.

AU - Muir, Kenneth R.

AU - Leongamornlert, Daniel A.

AU - Saunders, Edward

AU - Tymrakiewicz, Malgorzata

AU - Mahmud, Nadiya

AU - Guy, Michelle

AU - Govindasami, Koveela

AU - O'Brien, Lynne T.

AU - Wilkinson, Rosemary A.

AU - Hall, Amanda L.

AU - Sawyer, Emma J.

AU - Dadaev, Tokhir

AU - Morrison, Jonathan

AU - Dearnaley, David P.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Van As, Nicholas

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Dudderidge, Tim

AU - Ogden, Chris

AU - Cooper, Colin S.

AU - Lophatonanon, Artitaya

AU - Southey, Melissa C.

AU - Hopper, John L.

AU - English, Dallas

AU - Virtamo, Jarmo

AU - Marchand, Loic Le

AU - Campa, Daniele

AU - Kaaks, Rudolf

AU - Lindstrom, Sara

AU - Diver, W. Ryan

AU - Gapstur, Susan

AU - Yeager, Meredith

AU - Cox, Angela

AU - Stern, Mariana C.

AU - Corral, Roman

AU - Aly, Markus

AU - Isaacs, William

AU - Adolfsson, Jan

AU - Xu, Jianfeng

AU - Zheng, S. Lilly

AU - Wahlfors, Tiina

AU - Taari, Kimmo

AU - Kujala, Paula

AU - Klarskov, Peter

AU - Nordestgaard, Børge G.

AU - Røder, M. Andreas

AU - Frikke-Schmidt, Ruth

AU - Bojesen, Stig E.

AU - FitzGerald, Liesel M.

AU - Kolb, Suzanne

AU - Kwon, Erika M.

AU - Karyadi, Danielle M.

AU - Orntoft, Torben Falck

AU - Borre, Michael

AU - Rinckleb, Antje

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Meyer, Andreas

AU - Serth, Jü rgen

AU - Marthick, James R.

AU - Patterson, Briony

AU - Wokolorczyk, Dominika

AU - Spurdle, Amanda

AU - Lose, Felicity

AU - McDonnell, Shannon K.

AU - Joshi, Amit D.

AU - Shahabi, Ahva

AU - Pinto, Pedro

AU - Santos, Joana

AU - Ray, Ana

AU - Sellers, Thomas A.

AU - Lin, Hui Yi

AU - Stephenson, Robert A.

AU - Teerlink, Craig

AU - Muller, Heiko

AU - Rothenbacher, Dietrich

AU - Tsuchiya, Norihiko

AU - Narita, Shintaro

AU - Cao, Guang Wen

AU - Slavov, Chavdar

AU - Mitev, Vanio

AU - Chanock, Stephen

AU - Gronberg, Henrik

AU - Haiman, Christopher A.

AU - Kraft, Peter

AU - Easton, Douglas F.

AU - Eeles, Rosalind A.

PY - 2013/1

Y1 - 2013/1

N2 - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

AB - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

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