A mathematical model for brain tumor response to radiation therapy

R. Rockne, E. C. Alvord, J. K. Rockhill, Kristin Swanson

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Gliomas are highly invasive primary brain tumors, accounting for nearly 50% of all brain tumors (Alvord and Shaw in The pathology of the aging human nervous system. Lea & Febiger, Philadelphia, pp 210-281, 1991). Their aggressive growth leads to short life expectancies, as well as a fairly algorithmic approach to treatment: diagnostic magnetic resonance image (MRI) followed by biopsy or surgical resection with accompanying second MRI, external beam radiation therapy concurrent with and followed by chemotherapy, with MRIs conducted at various times during treatment as prescribed by the physician. Swanson et al. (Harpold et al. in J Neuropathol Exp Neurol 66:1-9, 2007) have shown that the defining and essential characteristics of gliomas in terms of net rates of proliferation (ρ) and invasion (D) can be determined from serial MRIs of individual patients. We present an extension to Swanson's reaction-diffusion model to include the effects of radiation therapy using the classic linear-quadratic radiobiological model (Hall in Radiobiology for the radiologist. Lippincott, Philadelphia, pp 478-480, 1994) for radiation efficacy, along with an investigation of response to various therapy schedules and dose distributions on a virtual tumor (Swanson et al. in AACR annual meeting, Los Angeles, 2007).

Original languageEnglish (US)
Pages (from-to)561-578
Number of pages18
JournalJournal of Mathematical Biology
Volume58
Issue number4-5
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Radiation Therapy
Brain Tumor
Magnetic Resonance Image
Radiotherapy
radiotherapy
Brain Neoplasms
Tumors
Brain
Theoretical Models
mathematical models
Magnetic resonance
Mathematical Model
Mathematical models
brain
Life Expectancy
Glioma
Magnetic resonance imaging
neoplasms
Reaction-diffusion Model
Chemotherapy

Keywords

  • Glioma
  • Linear-quadratic
  • Modeling
  • Radiation therapy
  • Treatment fractionation
  • Tumor response

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics
  • Modeling and Simulation

Cite this

A mathematical model for brain tumor response to radiation therapy. / Rockne, R.; Alvord, E. C.; Rockhill, J. K.; Swanson, Kristin.

In: Journal of Mathematical Biology, Vol. 58, No. 4-5, 04.2009, p. 561-578.

Research output: Contribution to journalArticle

Rockne, R. ; Alvord, E. C. ; Rockhill, J. K. ; Swanson, Kristin. / A mathematical model for brain tumor response to radiation therapy. In: Journal of Mathematical Biology. 2009 ; Vol. 58, No. 4-5. pp. 561-578.
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