A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety

Stephen Perry Whiteside, John D Port, Brett J. Deacon, Jonathan S. Abramowitz

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The aim of the current study was to use proton magnetic resonance spectroscopy (MRS) to investigate potential irregularities in neurochemical compounds in obsessive-compulsive disorder (OCD) and the extent to which these irregularities are related to state anxiety. Single voxel MRS was used to image the head of the caudate nucleus (HOC) and orbitofrontal white matter (OFWM) bilaterally in adult patients with OCD and a control group. The results indicated that patients with OCD had increased levels of a combined measure of glutamate and glutamine (Glx/Cr) and N-acetyl-l-aspartic acid (NAA/Cr) relative to creatine in the right OFWM and reduced levels of myo-inositol relative to creatine (mI/Cr) in the HOC bilaterally. Correlational analyses indicated that Glx/Cr in the OFWM was related to OCD symptoms, while mI/Cr in the HOC was related to trait and/or state anxiety. Reanalysis of the significant group differences controlling for state anxiety symptoms erased three of the four group differences. These results are discussed in context of the methodological difficulties facing this area of research.

Original languageEnglish (US)
Pages (from-to)137-147
Number of pages11
JournalPsychiatry Research - Neuroimaging
Volume146
Issue number2
DOIs
StatePublished - Mar 31 2006

Fingerprint

Obsessive-Compulsive Disorder
Magnetic Resonance Spectroscopy
Anxiety
Creatine
Caudate Nucleus
Inositol
Glutamine
Aspartic Acid
Glutamic Acid
Control Groups
Research
White Matter

Keywords

  • Anxiety
  • Caudate
  • Magnetic resonance spectroscopy
  • Neuroimaging
  • Obsessive-compulsive disorder
  • Orbitofrontal white matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety. / Whiteside, Stephen Perry; Port, John D; Deacon, Brett J.; Abramowitz, Jonathan S.

In: Psychiatry Research - Neuroimaging, Vol. 146, No. 2, 31.03.2006, p. 137-147.

Research output: Contribution to journalArticle

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