A low pretransplant peripheral blood mononuclear cell complex I activity predicts metabolic disturbances and inability to regain fat free mass in cirrhotic patients undergoing liver transplantation

Francoise Briet, Bashar A. Aqel, Khursheed N. Jeejeebhoy, James S. Scolapio

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Liver cirrhosis is associated with malnutrition and often, after liver transplantation, with the development of obesity and the inability to gain lean body mass. We have previously shown that peripheral blood mononuclear cell (PBMNC) complex I activity could be an appropriate marker for nutritional assessment. In this context, we hypothesized that a low pretransplant PBMNC complex I activity may predict a poor nutritional status in cirrhotic patients undergoing liver transplantation. Fifteen cirrhotic patients (CP) (8 men and 7 women) were recruited and investigated before and 4 months after liver transplantation. Body weight, body composition by DEXA, anthropometric measures (triceps skinfold thickness and midarm muscle circumference), resting energy expenditure, respiratory quotient and PBMNC complex I activity were measured on both time points. Patients were divided into 2 groups depending on their pretransplant PBMNC complex I activity (low vs high complex I activity [CPlow CI vs CPhigh CI]), using as an arbitrary cutoff value-the mean complex I activity observed in age-matched healthy controls. Before transplantation, the CPlow CI group who showed a lower complex I activity (2.11 ± 0.53 vs 4.54 ± 0.98 nmol/min per milligram of protein, P < .01) was significantly younger (44 ± 9 vs 62 ± 8 years old, P < .01); no differences were observed for any other nutritional parameters when compared to the CPhigh CI group. After transplantation, only the CPlow CI group demonstrated a significant increase of complex I activity (+77%, P < .01), respiratory quotient (+10.5%, P < .02), triceps skinfold thickness (+126%, P < .005), and a significant decrease of fat-free mass (-8%, P < .01). In summary, our findings indicate that a low pretransplant PBMNC complex I activity in cirrhotic patients could be a useful marker of poor nutritional status despite the lack of traditional indicators of malnutrition by predicting metabolic disturbances and an inability to regain fat-free mass after liver transplantation.

Original languageEnglish (US)
Pages (from-to)26-34
Number of pages9
JournalNutrition Research
Volume29
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Liver Transplantation
Blood Cells
Fats
Skinfold Thickness
Nutritional Status
Malnutrition
Transplantation
Nutrition Assessment
Body Composition
Liver Cirrhosis
Energy Metabolism
Obesity
Body Weight
Muscles
Proteins

Keywords

  • Body composition
  • Cirrhosis
  • Humans
  • Liver transplantation
  • Metabolism
  • Mitochondrial complex I
  • Peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

A low pretransplant peripheral blood mononuclear cell complex I activity predicts metabolic disturbances and inability to regain fat free mass in cirrhotic patients undergoing liver transplantation. / Briet, Francoise; Aqel, Bashar A.; Jeejeebhoy, Khursheed N.; Scolapio, James S.

In: Nutrition Research, Vol. 29, No. 1, 01.2009, p. 26-34.

Research output: Contribution to journalArticle

@article{63c3dd5b81d948159239c2207dfb24ff,
title = "A low pretransplant peripheral blood mononuclear cell complex I activity predicts metabolic disturbances and inability to regain fat free mass in cirrhotic patients undergoing liver transplantation",
abstract = "Liver cirrhosis is associated with malnutrition and often, after liver transplantation, with the development of obesity and the inability to gain lean body mass. We have previously shown that peripheral blood mononuclear cell (PBMNC) complex I activity could be an appropriate marker for nutritional assessment. In this context, we hypothesized that a low pretransplant PBMNC complex I activity may predict a poor nutritional status in cirrhotic patients undergoing liver transplantation. Fifteen cirrhotic patients (CP) (8 men and 7 women) were recruited and investigated before and 4 months after liver transplantation. Body weight, body composition by DEXA, anthropometric measures (triceps skinfold thickness and midarm muscle circumference), resting energy expenditure, respiratory quotient and PBMNC complex I activity were measured on both time points. Patients were divided into 2 groups depending on their pretransplant PBMNC complex I activity (low vs high complex I activity [CPlow CI vs CPhigh CI]), using as an arbitrary cutoff value-the mean complex I activity observed in age-matched healthy controls. Before transplantation, the CPlow CI group who showed a lower complex I activity (2.11 ± 0.53 vs 4.54 ± 0.98 nmol/min per milligram of protein, P < .01) was significantly younger (44 ± 9 vs 62 ± 8 years old, P < .01); no differences were observed for any other nutritional parameters when compared to the CPhigh CI group. After transplantation, only the CPlow CI group demonstrated a significant increase of complex I activity (+77{\%}, P < .01), respiratory quotient (+10.5{\%}, P < .02), triceps skinfold thickness (+126{\%}, P < .005), and a significant decrease of fat-free mass (-8{\%}, P < .01). In summary, our findings indicate that a low pretransplant PBMNC complex I activity in cirrhotic patients could be a useful marker of poor nutritional status despite the lack of traditional indicators of malnutrition by predicting metabolic disturbances and an inability to regain fat-free mass after liver transplantation.",
keywords = "Body composition, Cirrhosis, Humans, Liver transplantation, Metabolism, Mitochondrial complex I, Peripheral blood mononuclear cells",
author = "Francoise Briet and Aqel, {Bashar A.} and Jeejeebhoy, {Khursheed N.} and Scolapio, {James S.}",
year = "2009",
month = "1",
doi = "10.1016/j.nutres.2008.10.004",
language = "English (US)",
volume = "29",
pages = "26--34",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - A low pretransplant peripheral blood mononuclear cell complex I activity predicts metabolic disturbances and inability to regain fat free mass in cirrhotic patients undergoing liver transplantation

AU - Briet, Francoise

AU - Aqel, Bashar A.

AU - Jeejeebhoy, Khursheed N.

AU - Scolapio, James S.

PY - 2009/1

Y1 - 2009/1

N2 - Liver cirrhosis is associated with malnutrition and often, after liver transplantation, with the development of obesity and the inability to gain lean body mass. We have previously shown that peripheral blood mononuclear cell (PBMNC) complex I activity could be an appropriate marker for nutritional assessment. In this context, we hypothesized that a low pretransplant PBMNC complex I activity may predict a poor nutritional status in cirrhotic patients undergoing liver transplantation. Fifteen cirrhotic patients (CP) (8 men and 7 women) were recruited and investigated before and 4 months after liver transplantation. Body weight, body composition by DEXA, anthropometric measures (triceps skinfold thickness and midarm muscle circumference), resting energy expenditure, respiratory quotient and PBMNC complex I activity were measured on both time points. Patients were divided into 2 groups depending on their pretransplant PBMNC complex I activity (low vs high complex I activity [CPlow CI vs CPhigh CI]), using as an arbitrary cutoff value-the mean complex I activity observed in age-matched healthy controls. Before transplantation, the CPlow CI group who showed a lower complex I activity (2.11 ± 0.53 vs 4.54 ± 0.98 nmol/min per milligram of protein, P < .01) was significantly younger (44 ± 9 vs 62 ± 8 years old, P < .01); no differences were observed for any other nutritional parameters when compared to the CPhigh CI group. After transplantation, only the CPlow CI group demonstrated a significant increase of complex I activity (+77%, P < .01), respiratory quotient (+10.5%, P < .02), triceps skinfold thickness (+126%, P < .005), and a significant decrease of fat-free mass (-8%, P < .01). In summary, our findings indicate that a low pretransplant PBMNC complex I activity in cirrhotic patients could be a useful marker of poor nutritional status despite the lack of traditional indicators of malnutrition by predicting metabolic disturbances and an inability to regain fat-free mass after liver transplantation.

AB - Liver cirrhosis is associated with malnutrition and often, after liver transplantation, with the development of obesity and the inability to gain lean body mass. We have previously shown that peripheral blood mononuclear cell (PBMNC) complex I activity could be an appropriate marker for nutritional assessment. In this context, we hypothesized that a low pretransplant PBMNC complex I activity may predict a poor nutritional status in cirrhotic patients undergoing liver transplantation. Fifteen cirrhotic patients (CP) (8 men and 7 women) were recruited and investigated before and 4 months after liver transplantation. Body weight, body composition by DEXA, anthropometric measures (triceps skinfold thickness and midarm muscle circumference), resting energy expenditure, respiratory quotient and PBMNC complex I activity were measured on both time points. Patients were divided into 2 groups depending on their pretransplant PBMNC complex I activity (low vs high complex I activity [CPlow CI vs CPhigh CI]), using as an arbitrary cutoff value-the mean complex I activity observed in age-matched healthy controls. Before transplantation, the CPlow CI group who showed a lower complex I activity (2.11 ± 0.53 vs 4.54 ± 0.98 nmol/min per milligram of protein, P < .01) was significantly younger (44 ± 9 vs 62 ± 8 years old, P < .01); no differences were observed for any other nutritional parameters when compared to the CPhigh CI group. After transplantation, only the CPlow CI group demonstrated a significant increase of complex I activity (+77%, P < .01), respiratory quotient (+10.5%, P < .02), triceps skinfold thickness (+126%, P < .005), and a significant decrease of fat-free mass (-8%, P < .01). In summary, our findings indicate that a low pretransplant PBMNC complex I activity in cirrhotic patients could be a useful marker of poor nutritional status despite the lack of traditional indicators of malnutrition by predicting metabolic disturbances and an inability to regain fat-free mass after liver transplantation.

KW - Body composition

KW - Cirrhosis

KW - Humans

KW - Liver transplantation

KW - Metabolism

KW - Mitochondrial complex I

KW - Peripheral blood mononuclear cells

UR - http://www.scopus.com/inward/record.url?scp=58649085265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58649085265&partnerID=8YFLogxK

U2 - 10.1016/j.nutres.2008.10.004

DO - 10.1016/j.nutres.2008.10.004

M3 - Article

C2 - 19185774

AN - SCOPUS:58649085265

VL - 29

SP - 26

EP - 34

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 1

ER -