A longitudinal study of the JAK2V617F mutation in myelofibrosis with myeloid metaplasia: Analysis at two time points

Ruben A. Mesa, Heather Powell, Terra Lasho, Goron W. DeWald, Rebecca McClure, Ayalew Tefferi

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.

Original languageEnglish (US)
Pages (from-to)415-416
Number of pages2
JournalHaematologica
Volume91
Issue number3
StatePublished - Mar 1 2006

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Keywords

  • JAK2
  • Leukemic transformation
  • Myelofibrosis with myeloid metaplasia
  • Myeloproliferative disorders

ASJC Scopus subject areas

  • Hematology

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