A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions

Andreas Bitsch; Tanja Kuhlmann; Christine Stadelmann; Hans Lassmann; Claudia Lucchinetti; Wolfgang Brück

doi:10.1002/ana.1053

A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions

Andreas Bitsch, Tanja Kuhlmann, Christine Stadelmann, Hans Lassmann, Claudia Lucchinetti, Wolfgang Brück

Neurology

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166 Scopus citations

Abstract

Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.

Original language	English (US)
Pages (from-to)	793-796
Number of pages	4
Journal	Annals of neurology
Volume	49
Issue number	6
DOIs	https://doi.org/10.1002/ana.1053
State	Published - 2001

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.1053

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AU - Bitsch, Andreas

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AU - Stadelmann, Christine

AU - Lassmann, Hans

AU - Lucchinetti, Claudia

AU - Brück, Wolfgang

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AB - Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.

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A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions

Abstract

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