A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions

Andreas Bitsch, Tanja Kuhlmann, Christine Stadelmann, Hans Lassmann, Claudia F Lucchinetti, Wolfgang Brück

Research output: Contribution to journalArticle

159 Scopus citations


Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.

Original languageEnglish (US)
Pages (from-to)793-796
Number of pages4
JournalAnnals of Neurology
Issue number6
StatePublished - 2001


ASJC Scopus subject areas

  • Neuroscience(all)

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