A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer

Jianliang Shen, Han Cheon Kim, Joy Wolfram, Chaofeng Mu, Wei Zhang, Haoran Liu, Yan Xie, Junhua Mai, Hang Zhang, Zhi Li, Maria Guevara, Zong Wan Mao, Haifa Shen

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Ruthenium coordination complexes have the potential to serve as novel theranostic agents for cancer. However, a major limitation in their clinical implementation is effective tumor accumulation. In this study, we have developed a liposome-based theranostic nanodelivery system for [Ru(phen)2dppz](ClO4)2 (Lipo-Ru). This ruthenium polypyridine complex emits a strong fluorescent signal when incorporated in the hydrophobic lipid bilayer of the delivery vehicle or in the DNA helix, enabling visualization of the therapeutic agent in tumor tissues. Incubation of MDA-MB-231 breast cancer cells with Lipo-Ru induced double-strand DNA breaks and triggers apoptosis. In a mouse model of triple-negative breast cancer, treatment with Lipo-Ru dramatically reduced tumor growth. Biodistribution studies of Lipo-Ru revealed that more than 20% of the injected dose accumulated in the tumor. These results suggest that Lipo-Ru could serve as a promising theranostic platform for cancer.

Original languageEnglish (US)
Pages (from-to)2913-2920
Number of pages8
JournalNano Letters
Volume17
Issue number5
DOIs
StatePublished - May 10 2017

Fingerprint

Ruthenium
Liposomes
breast
ruthenium
Tumors
tumors
platforms
cancer
DNA
deoxyribonucleic acid
multiple docking adapters
Lipid bilayers
Oncology
Coordination Complexes
apoptosis
Cell death
strands
helices
mice
lipids

Keywords

  • Liposome
  • nanoplatform
  • ruthenium polypyridine complex
  • theranostic
  • triple-negative breast cancer

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer. / Shen, Jianliang; Kim, Han Cheon; Wolfram, Joy; Mu, Chaofeng; Zhang, Wei; Liu, Haoran; Xie, Yan; Mai, Junhua; Zhang, Hang; Li, Zhi; Guevara, Maria; Mao, Zong Wan; Shen, Haifa.

In: Nano Letters, Vol. 17, No. 5, 10.05.2017, p. 2913-2920.

Research output: Contribution to journalArticle

Shen, J, Kim, HC, Wolfram, J, Mu, C, Zhang, W, Liu, H, Xie, Y, Mai, J, Zhang, H, Li, Z, Guevara, M, Mao, ZW & Shen, H 2017, 'A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer', Nano Letters, vol. 17, no. 5, pp. 2913-2920. https://doi.org/10.1021/acs.nanolett.7b00132
Shen, Jianliang ; Kim, Han Cheon ; Wolfram, Joy ; Mu, Chaofeng ; Zhang, Wei ; Liu, Haoran ; Xie, Yan ; Mai, Junhua ; Zhang, Hang ; Li, Zhi ; Guevara, Maria ; Mao, Zong Wan ; Shen, Haifa. / A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer. In: Nano Letters. 2017 ; Vol. 17, No. 5. pp. 2913-2920.
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