A limited role for DJ1 in Parkinson disease susceptibility

D. M. Maraganore, K. Wilkes, T. G. Lesnick, K. J. Strain, M. De Andrade, W. A. Rocca, J. H. Bower, J. E. Ahlskog, S. Lincoln, M. J. Farrer

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. PD probands were compared with their unaffected siblings matched by gender and closest age at study (416 vs 416) and with unrelated control subjects (691 vs 190). None of the four haplotype tagging single-nucleotide polymorphisms (SNPs) was associated with PD overall, but SNP1 (position 4,345 bp) and SNP3 (position 16,491 bp) were associated with PD in women (p = 0.03 and p = 0.002).

Original languageEnglish (US)
Pages (from-to)550-553
Number of pages4
JournalNeurology
Volume63
Issue number3
DOIs
StatePublished - Aug 10 2004

ASJC Scopus subject areas

  • Clinical Neurology

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    Maraganore, D. M., Wilkes, K., Lesnick, T. G., Strain, K. J., De Andrade, M., Rocca, W. A., Bower, J. H., Ahlskog, J. E., Lincoln, S., & Farrer, M. J. (2004). A limited role for DJ1 in Parkinson disease susceptibility. Neurology, 63(3), 550-553. https://doi.org/10.1212/01.WNL.0000133402.78621.AD