A limited role for DJ1 in Parkinson disease susceptibility

D. M. Maraganore, K. Wilkes, T. G. Lesnick, K. J. Strain, Mariza De Andrade, Walter A Rocca, James Howard Bower, J. E. Ahlskog, S. Lincoln, M. J. Farrer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. PD probands were compared with their unaffected siblings matched by gender and closest age at study (416 vs 416) and with unrelated control subjects (691 vs 190). None of the four haplotype tagging single-nucleotide polymorphisms (SNPs) was associated with PD overall, but SNP1 (position 4,345 bp) and SNP3 (position 16,491 bp) were associated with PD in women (p = 0.03 and p = 0.002).

Original languageEnglish (US)
Pages (from-to)550-553
Number of pages4
JournalNeurology
Volume63
Issue number3
StatePublished - Aug 10 2004

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Disease Susceptibility
Parkinson Disease
Haplotypes
Single Nucleotide Polymorphism
Siblings
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maraganore, D. M., Wilkes, K., Lesnick, T. G., Strain, K. J., De Andrade, M., Rocca, W. A., ... Farrer, M. J. (2004). A limited role for DJ1 in Parkinson disease susceptibility. Neurology, 63(3), 550-553.

A limited role for DJ1 in Parkinson disease susceptibility. / Maraganore, D. M.; Wilkes, K.; Lesnick, T. G.; Strain, K. J.; De Andrade, Mariza; Rocca, Walter A; Bower, James Howard; Ahlskog, J. E.; Lincoln, S.; Farrer, M. J.

In: Neurology, Vol. 63, No. 3, 10.08.2004, p. 550-553.

Research output: Contribution to journalArticle

Maraganore, DM, Wilkes, K, Lesnick, TG, Strain, KJ, De Andrade, M, Rocca, WA, Bower, JH, Ahlskog, JE, Lincoln, S & Farrer, MJ 2004, 'A limited role for DJ1 in Parkinson disease susceptibility', Neurology, vol. 63, no. 3, pp. 550-553.
Maraganore DM, Wilkes K, Lesnick TG, Strain KJ, De Andrade M, Rocca WA et al. A limited role for DJ1 in Parkinson disease susceptibility. Neurology. 2004 Aug 10;63(3):550-553.
Maraganore, D. M. ; Wilkes, K. ; Lesnick, T. G. ; Strain, K. J. ; De Andrade, Mariza ; Rocca, Walter A ; Bower, James Howard ; Ahlskog, J. E. ; Lincoln, S. ; Farrer, M. J. / A limited role for DJ1 in Parkinson disease susceptibility. In: Neurology. 2004 ; Vol. 63, No. 3. pp. 550-553.
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