A Large Set of Finnish Affected Sibling Pair Families with Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

Kaisa Silander; Laura J. Scott; Timo T. Valle; Karen L. Mohlke; Heather M. Stringham; Kerry R. Wiles; William L. Duren; Kimberly F. Doheny; Elizabeth W. Pugh; Peter Chines; Narisu Narisu; Peggy P. White; Tasha E. Fingerlin; Anne U. Jackson; Chun Li; Soumitra Ghosh; Victoria L. Magnuson; Kimberly Colby; Michael R. Erdos; Jason E. Hill; Pablo Hollstein; Kathleen M. Humphreys; Roshni A. Kasad; Jessica Lambert; Konstantinos N. Lazaridis; George Lin; Anabelle Morales-Mena; Kristin Patzkowski; Carrie Pfahl; Rachel Porter; David Rha; Leonid Segal; Yong D. Suh; Jason Tovar; Arun Unni; Christian Welch; Julie A. Douglas; Michael P. Epstein; Elizabeth R. Hauser; William Hagopian; Thomas A. Buchanan; Richard M. Watanabe; Richard N. Bergman; Jaakko Tuomilehto; Francis S. Collins; Michael Boehnke

doi:10.2337/diabetes.53.3.821

A Large Set of Finnish Affected Sibling Pair Families with Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

Kaisa Silander, Laura J. Scott, Timo T. Valle, Karen L. Mohlke, Heather M. Stringham, Kerry R. Wiles, William L. Duren, Kimberly F. Doheny, Elizabeth W. Pugh, Peter Chines, Narisu Narisu, Peggy P. White, Tasha E. Fingerlin, Anne U. Jackson, Chun Li, Soumitra Ghosh, Victoria L. Magnuson, Kimberly Colby, Michael R. Erdos, Jason E. HillPablo Hollstein, Kathleen M. Humphreys, Roshni A. Kasad, Jessica Lambert, Konstantinos N. Lazaridis, George Lin, Anabelle Morales-Mena, Kristin Patzkowski, Carrie Pfahl, Rachel Porter, David Rha, Leonid Segal, Yong D. Suh, Jason Tovar, Arun Unni, Christian Welch, Julie A. Douglas, Michael P. Epstein, Elizabeth R. Hauser, William Hagopian, Thomas A. Buchanan, Richard M. Watanabe, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Michael Boehnke

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

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Abstract

The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidate gene approach. In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage results were on chromosomes 20 and 11. We now report a second genome-wide scan using an independent set of 242 Finnish ASP families (FUSION 2), a detailed analysis of the combined set of 737 FUSION 1 + 2 families (495 updated FUSION 1 families), and fine mapping of the regions of chromosomes 11 and 20. The strongest FUSION 2 linkage results were on chromosomes 6 (maximum logarithm of odds score [MLS] = 2.30 at 95 cM) and 14 (MLS = 1.80 at 57 cM). For the combined FUSION 1 + 2 families, three results were particularly notable: chromosome 11 (MLS = 2.98 at 82 cM), chromosome 14 (MLS = 2.74 at 58 cM), and chromosome 6 (MLS = 2.66 at 96 cM). We obtained smaller FUSION 1 + 2 MLSs on chromosomes X (MLS = 1.27 at 152 cM) and 20p (MLS = 1.21 at 20 cM). Among the 10 regions that showed nominally significant evidence for linkage in FUSION 1, four (on chromosomes 6, 11, 14, and X) also showed evidence for linkage in FUSION 2 and stronger evidence for linkage in the combined FUSION 1 + 2 sample.

Original language	English (US)
Pages (from-to)	821-829
Number of pages	9
Journal	Diabetes
Volume	53
Issue number	3
DOIs	https://doi.org/10.2337/diabetes.53.3.821
State	Published - Mar 2004

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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Silander, K., Scott, L. J., Valle, T. T., Mohlke, K. L., Stringham, H. M., Wiles, K. R., Duren, W. L., Doheny, K. F., Pugh, E. W., Chines, P., Narisu, N., White, P. P., Fingerlin, T. E., Jackson, A. U., Li, C., Ghosh, S., Magnuson, V. L., Colby, K., Erdos, M. R., ... Boehnke, M. (2004). A Large Set of Finnish Affected Sibling Pair Families with Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14. Diabetes, 53(3), 821-829. https://doi.org/10.2337/diabetes.53.3.821

Silander, K, Scott, LJ, Valle, TT, Mohlke, KL, Stringham, HM, Wiles, KR, Duren, WL, Doheny, KF, Pugh, EW, Chines, P, Narisu, N, White, PP, Fingerlin, TE, Jackson, AU, Li, C, Ghosh, S, Magnuson, VL, Colby, K, Erdos, MR, Hill, JE, Hollstein, P, Humphreys, KM, Kasad, RA, Lambert, J, Lazaridis, KN, Lin, G, Morales-Mena, A, Patzkowski, K, Pfahl, C, Porter, R, Rha, D, Segal, L, Suh, YD, Tovar, J, Unni, A, Welch, C, Douglas, JA, Epstein, MP, Hauser, ER, Hagopian, W, Buchanan, TA, Watanabe, RM, Bergman, RN, Tuomilehto, J, Collins, FS & Boehnke, M 2004, 'A Large Set of Finnish Affected Sibling Pair Families with Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14', Diabetes, vol. 53, no. 3, pp. 821-829. https://doi.org/10.2337/diabetes.53.3.821

@article{8c9f0238b90545678c243d6d2c6ce95c,

title = "A Large Set of Finnish Affected Sibling Pair Families with Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14",

abstract = "The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidate gene approach. In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage results were on chromosomes 20 and 11. We now report a second genome-wide scan using an independent set of 242 Finnish ASP families (FUSION 2), a detailed analysis of the combined set of 737 FUSION 1 + 2 families (495 updated FUSION 1 families), and fine mapping of the regions of chromosomes 11 and 20. The strongest FUSION 2 linkage results were on chromosomes 6 (maximum logarithm of odds score [MLS] = 2.30 at 95 cM) and 14 (MLS = 1.80 at 57 cM). For the combined FUSION 1 + 2 families, three results were particularly notable: chromosome 11 (MLS = 2.98 at 82 cM), chromosome 14 (MLS = 2.74 at 58 cM), and chromosome 6 (MLS = 2.66 at 96 cM). We obtained smaller FUSION 1 + 2 MLSs on chromosomes X (MLS = 1.27 at 152 cM) and 20p (MLS = 1.21 at 20 cM). Among the 10 regions that showed nominally significant evidence for linkage in FUSION 1, four (on chromosomes 6, 11, 14, and X) also showed evidence for linkage in FUSION 2 and stronger evidence for linkage in the combined FUSION 1 + 2 sample.",

author = "Kaisa Silander and Scott, {Laura J.} and Valle, {Timo T.} and Mohlke, {Karen L.} and Stringham, {Heather M.} and Wiles, {Kerry R.} and Duren, {William L.} and Doheny, {Kimberly F.} and Pugh, {Elizabeth W.} and Peter Chines and Narisu Narisu and White, {Peggy P.} and Fingerlin, {Tasha E.} and Jackson, {Anne U.} and Chun Li and Soumitra Ghosh and Magnuson, {Victoria L.} and Kimberly Colby and Erdos, {Michael R.} and Hill, {Jason E.} and Pablo Hollstein and Humphreys, {Kathleen M.} and Kasad, {Roshni A.} and Jessica Lambert and Lazaridis, {Konstantinos N.} and George Lin and Anabelle Morales-Mena and Kristin Patzkowski and Carrie Pfahl and Rachel Porter and David Rha and Leonid Segal and Suh, {Yong D.} and Jason Tovar and Arun Unni and Christian Welch and Douglas, {Julie A.} and Epstein, {Michael P.} and Hauser, {Elizabeth R.} and William Hagopian and Buchanan, {Thomas A.} and Watanabe, {Richard M.} and Bergman, {Richard N.} and Jaakko Tuomilehto and Collins, {Francis S.} and Michael Boehnke",

year = "2004",

month = mar,

doi = "10.2337/diabetes.53.3.821",

language = "English (US)",

volume = "53",

pages = "821--829",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association Inc.",

number = "3",

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TY - JOUR

T1 - A Large Set of Finnish Affected Sibling Pair Families with Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

AU - Silander, Kaisa

AU - Scott, Laura J.

AU - Valle, Timo T.

AU - Mohlke, Karen L.

AU - Stringham, Heather M.

AU - Wiles, Kerry R.

AU - Duren, William L.

AU - Doheny, Kimberly F.

AU - Pugh, Elizabeth W.

AU - Chines, Peter

AU - Narisu, Narisu

AU - White, Peggy P.

AU - Fingerlin, Tasha E.

AU - Jackson, Anne U.

AU - Li, Chun

AU - Ghosh, Soumitra

AU - Magnuson, Victoria L.

AU - Colby, Kimberly

AU - Erdos, Michael R.

AU - Hill, Jason E.

AU - Hollstein, Pablo

AU - Humphreys, Kathleen M.

AU - Kasad, Roshni A.

AU - Lambert, Jessica

AU - Lazaridis, Konstantinos N.

AU - Lin, George

AU - Morales-Mena, Anabelle

AU - Patzkowski, Kristin

AU - Pfahl, Carrie

AU - Porter, Rachel

AU - Rha, David

AU - Segal, Leonid

AU - Suh, Yong D.

AU - Tovar, Jason

AU - Unni, Arun

AU - Welch, Christian

AU - Douglas, Julie A.

AU - Epstein, Michael P.

AU - Hauser, Elizabeth R.

AU - Hagopian, William

AU - Buchanan, Thomas A.

AU - Watanabe, Richard M.

AU - Bergman, Richard N.

AU - Tuomilehto, Jaakko

AU - Collins, Francis S.

AU - Boehnke, Michael

PY - 2004/3

Y1 - 2004/3

N2 - The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidate gene approach. In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage results were on chromosomes 20 and 11. We now report a second genome-wide scan using an independent set of 242 Finnish ASP families (FUSION 2), a detailed analysis of the combined set of 737 FUSION 1 + 2 families (495 updated FUSION 1 families), and fine mapping of the regions of chromosomes 11 and 20. The strongest FUSION 2 linkage results were on chromosomes 6 (maximum logarithm of odds score [MLS] = 2.30 at 95 cM) and 14 (MLS = 1.80 at 57 cM). For the combined FUSION 1 + 2 families, three results were particularly notable: chromosome 11 (MLS = 2.98 at 82 cM), chromosome 14 (MLS = 2.74 at 58 cM), and chromosome 6 (MLS = 2.66 at 96 cM). We obtained smaller FUSION 1 + 2 MLSs on chromosomes X (MLS = 1.27 at 152 cM) and 20p (MLS = 1.21 at 20 cM). Among the 10 regions that showed nominally significant evidence for linkage in FUSION 1, four (on chromosomes 6, 11, 14, and X) also showed evidence for linkage in FUSION 2 and stronger evidence for linkage in the combined FUSION 1 + 2 sample.

AB - The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidate gene approach. In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage results were on chromosomes 20 and 11. We now report a second genome-wide scan using an independent set of 242 Finnish ASP families (FUSION 2), a detailed analysis of the combined set of 737 FUSION 1 + 2 families (495 updated FUSION 1 families), and fine mapping of the regions of chromosomes 11 and 20. The strongest FUSION 2 linkage results were on chromosomes 6 (maximum logarithm of odds score [MLS] = 2.30 at 95 cM) and 14 (MLS = 1.80 at 57 cM). For the combined FUSION 1 + 2 families, three results were particularly notable: chromosome 11 (MLS = 2.98 at 82 cM), chromosome 14 (MLS = 2.74 at 58 cM), and chromosome 6 (MLS = 2.66 at 96 cM). We obtained smaller FUSION 1 + 2 MLSs on chromosomes X (MLS = 1.27 at 152 cM) and 20p (MLS = 1.21 at 20 cM). Among the 10 regions that showed nominally significant evidence for linkage in FUSION 1, four (on chromosomes 6, 11, 14, and X) also showed evidence for linkage in FUSION 2 and stronger evidence for linkage in the combined FUSION 1 + 2 sample.

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DO - 10.2337/diabetes.53.3.821

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SN - 0012-1797

VL - 53

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EP - 829

JO - Diabetes

JF - Diabetes

IS - 3

ER -

A Large Set of Finnish Affected Sibling Pair Families with Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

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