A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

Soumitra Ghosh, Elizabeth R. Hauser, Victoria L. Magnuson, Timo Valle, Delphine S. Ally, Zarir E. Karanjawala, Joseph B. Rayman, Julie I. Knapp, Anjene Musick, Joyce Tannenbaum, Catherine Te, William Eldridge, Shane A Shapiro, Tiffany Musick, Colin Martin, Alistair So, Alyson Witt, Julian Blaschak Harvan, Richard M. Watanabe, William Hagopian & 11 others Johan Eriksson, Stella J. Nylund, Kimmo Kohtamaki, Eva Tuomilehto-Wolf, Liisa Toivanen, Gabriele Vidgren, Christian Ehnholm, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Michael Boehnke

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.

Original languageEnglish (US)
Pages (from-to)704-709
Number of pages6
JournalJournal of Clinical Investigation
Volume102
Issue number4
DOIs
StatePublished - Aug 15 1998
Externally publishedYes

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Type 2 Diabetes Mellitus
Viverridae
Population
Siblings
Chromosomes
Genome
Noninsulin-Dependent Diabetes Mellitus 1

Keywords

  • Affected sib-pairs
  • Fluorescent genotyping
  • Gene mapping
  • Linkage analysis
  • Non-insulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. / Ghosh, Soumitra; Hauser, Elizabeth R.; Magnuson, Victoria L.; Valle, Timo; Ally, Delphine S.; Karanjawala, Zarir E.; Rayman, Joseph B.; Knapp, Julie I.; Musick, Anjene; Tannenbaum, Joyce; Te, Catherine; Eldridge, William; Shapiro, Shane A; Musick, Tiffany; Martin, Colin; So, Alistair; Witt, Alyson; Harvan, Julian Blaschak; Watanabe, Richard M.; Hagopian, William; Eriksson, Johan; Nylund, Stella J.; Kohtamaki, Kimmo; Tuomilehto-Wolf, Eva; Toivanen, Liisa; Vidgren, Gabriele; Ehnholm, Christian; Bergman, Richard N.; Tuomilehto, Jaakko; Collins, Francis S.; Boehnke, Michael.

In: Journal of Clinical Investigation, Vol. 102, No. 4, 15.08.1998, p. 704-709.

Research output: Contribution to journalArticle

Ghosh, S, Hauser, ER, Magnuson, VL, Valle, T, Ally, DS, Karanjawala, ZE, Rayman, JB, Knapp, JI, Musick, A, Tannenbaum, J, Te, C, Eldridge, W, Shapiro, SA, Musick, T, Martin, C, So, A, Witt, A, Harvan, JB, Watanabe, RM, Hagopian, W, Eriksson, J, Nylund, SJ, Kohtamaki, K, Tuomilehto-Wolf, E, Toivanen, L, Vidgren, G, Ehnholm, C, Bergman, RN, Tuomilehto, J, Collins, FS & Boehnke, M 1998, 'A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter', Journal of Clinical Investigation, vol. 102, no. 4, pp. 704-709. https://doi.org/10.1172/JCI2512
Ghosh, Soumitra ; Hauser, Elizabeth R. ; Magnuson, Victoria L. ; Valle, Timo ; Ally, Delphine S. ; Karanjawala, Zarir E. ; Rayman, Joseph B. ; Knapp, Julie I. ; Musick, Anjene ; Tannenbaum, Joyce ; Te, Catherine ; Eldridge, William ; Shapiro, Shane A ; Musick, Tiffany ; Martin, Colin ; So, Alistair ; Witt, Alyson ; Harvan, Julian Blaschak ; Watanabe, Richard M. ; Hagopian, William ; Eriksson, Johan ; Nylund, Stella J. ; Kohtamaki, Kimmo ; Tuomilehto-Wolf, Eva ; Toivanen, Liisa ; Vidgren, Gabriele ; Ehnholm, Christian ; Bergman, Richard N. ; Tuomilehto, Jaakko ; Collins, Francis S. ; Boehnke, Michael. / A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. In: Journal of Clinical Investigation. 1998 ; Vol. 102, No. 4. pp. 704-709.
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abstract = "In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.",
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T1 - A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

AU - Ghosh, Soumitra

AU - Hauser, Elizabeth R.

AU - Magnuson, Victoria L.

AU - Valle, Timo

AU - Ally, Delphine S.

AU - Karanjawala, Zarir E.

AU - Rayman, Joseph B.

AU - Knapp, Julie I.

AU - Musick, Anjene

AU - Tannenbaum, Joyce

AU - Te, Catherine

AU - Eldridge, William

AU - Shapiro, Shane A

AU - Musick, Tiffany

AU - Martin, Colin

AU - So, Alistair

AU - Witt, Alyson

AU - Harvan, Julian Blaschak

AU - Watanabe, Richard M.

AU - Hagopian, William

AU - Eriksson, Johan

AU - Nylund, Stella J.

AU - Kohtamaki, Kimmo

AU - Tuomilehto-Wolf, Eva

AU - Toivanen, Liisa

AU - Vidgren, Gabriele

AU - Ehnholm, Christian

AU - Bergman, Richard N.

AU - Tuomilehto, Jaakko

AU - Collins, Francis S.

AU - Boehnke, Michael

PY - 1998/8/15

Y1 - 1998/8/15

N2 - In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.

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