A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

Soumitra Ghosh; Elizabeth R. Hauser; Victoria L. Magnuson; Timo Valle; Delphine S. Ally; Zarir E. Karanjawala; Joseph B. Rayman; Julie I. Knapp; Anjene Musick; Joyce Tannenbaum; Catherine Te; William Eldridge; Shane Shapiro; Tiffany Musick; Colin Martin; Alistair So; Alyson Witt; Julian Blaschak Harvan; Richard M. Watanabe; William Hagopian; Johan Eriksson; Stella J. Nylund; Kimmo Kohtamaki; Eva Tuomilehto-Wolf; Liisa Toivanen; Gabriele Vidgren; Christian Ehnholm; Richard N. Bergman; Jaakko Tuomilehto; Francis S. Collins; Michael Boehnke

doi:10.1172/JCI2512

A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

Soumitra Ghosh, Elizabeth R. Hauser, Victoria L. Magnuson, Timo Valle, Delphine S. Ally, Zarir E. Karanjawala, Joseph B. Rayman, Julie I. Knapp, Anjene Musick, Joyce Tannenbaum, Catherine Te, William Eldridge, Shane Shapiro, Tiffany Musick, Colin Martin, Alistair So, Alyson Witt, Julian Blaschak Harvan, Richard M. Watanabe, William HagopianJohan Eriksson, Stella J. Nylund, Kimmo Kohtamaki, Eva Tuomilehto-Wolf, Liisa Toivanen, Gabriele Vidgren, Christian Ehnholm, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Michael Boehnke

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Abstract

In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.

Original language	English (US)
Pages (from-to)	704-709
Number of pages	6
Journal	Journal of Clinical Investigation
Volume	102
Issue number	4
DOIs	https://doi.org/10.1172/JCI2512
State	Published - Aug 15 1998

Keywords

Affected sib-pairs
Fluorescent genotyping
Gene mapping
Linkage analysis
Non-insulin-dependent diabetes mellitus

ASJC Scopus subject areas

General Medicine

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10.1172/JCI2512

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Ghosh, S., Hauser, E. R., Magnuson, V. L., Valle, T., Ally, D. S., Karanjawala, Z. E., Rayman, J. B., Knapp, J. I., Musick, A., Tannenbaum, J., Te, C., Eldridge, W., Shapiro, S., Musick, T., Martin, C., So, A., Witt, A., Harvan, J. B., Watanabe, R. M., ... Boehnke, M. (1998). A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. Journal of Clinical Investigation, 102(4), 704-709. https://doi.org/10.1172/JCI2512

Ghosh, S, Hauser, ER, Magnuson, VL, Valle, T, Ally, DS, Karanjawala, ZE, Rayman, JB, Knapp, JI, Musick, A, Tannenbaum, J, Te, C, Eldridge, W, Shapiro, S, Musick, T, Martin, C, So, A, Witt, A, Harvan, JB, Watanabe, RM, Hagopian, W, Eriksson, J, Nylund, SJ, Kohtamaki, K, Tuomilehto-Wolf, E, Toivanen, L, Vidgren, G, Ehnholm, C, Bergman, RN, Tuomilehto, J, Collins, FS & Boehnke, M 1998, 'A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter', Journal of Clinical Investigation, vol. 102, no. 4, pp. 704-709. https://doi.org/10.1172/JCI2512

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title = "A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter",

abstract = "In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.",

keywords = "Affected sib-pairs, Fluorescent genotyping, Gene mapping, Linkage analysis, Non-insulin-dependent diabetes mellitus",

author = "Soumitra Ghosh and Hauser, {Elizabeth R.} and Magnuson, {Victoria L.} and Timo Valle and Ally, {Delphine S.} and Karanjawala, {Zarir E.} and Rayman, {Joseph B.} and Knapp, {Julie I.} and Anjene Musick and Joyce Tannenbaum and Catherine Te and William Eldridge and Shane Shapiro and Tiffany Musick and Colin Martin and Alistair So and Alyson Witt and Harvan, {Julian Blaschak} and Watanabe, {Richard M.} and William Hagopian and Johan Eriksson and Nylund, {Stella J.} and Kimmo Kohtamaki and Eva Tuomilehto-Wolf and Liisa Toivanen and Gabriele Vidgren and Christian Ehnholm and Bergman, {Richard N.} and Jaakko Tuomilehto and Collins, {Francis S.} and Michael Boehnke",

year = "1998",

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doi = "10.1172/JCI2512",

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T1 - A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

AU - Ghosh, Soumitra

AU - Hauser, Elizabeth R.

AU - Magnuson, Victoria L.

AU - Valle, Timo

AU - Ally, Delphine S.

AU - Karanjawala, Zarir E.

AU - Rayman, Joseph B.

AU - Knapp, Julie I.

AU - Musick, Anjene

AU - Tannenbaum, Joyce

AU - Te, Catherine

AU - Eldridge, William

AU - Shapiro, Shane

AU - Musick, Tiffany

AU - Martin, Colin

AU - So, Alistair

AU - Witt, Alyson

AU - Harvan, Julian Blaschak

AU - Watanabe, Richard M.

AU - Hagopian, William

AU - Eriksson, Johan

AU - Nylund, Stella J.

AU - Kohtamaki, Kimmo

AU - Tuomilehto-Wolf, Eva

AU - Toivanen, Liisa

AU - Vidgren, Gabriele

AU - Ehnholm, Christian

AU - Bergman, Richard N.

AU - Tuomilehto, Jaakko

AU - Collins, Francis S.

AU - Boehnke, Michael

PY - 1998/8/15

Y1 - 1998/8/15

N2 - In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.

AB - In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.

KW - Affected sib-pairs

KW - Fluorescent genotyping

KW - Gene mapping

KW - Linkage analysis

KW - Non-insulin-dependent diabetes mellitus

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ER -

A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

Abstract

Keywords

ASJC Scopus subject areas

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