A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

Soumitra Ghosh, Elizabeth R. Hauser, Victoria L. Magnuson, Timo Valle, Delphine S. Ally, Zarir E. Karanjawala, Joseph B. Rayman, Julie I. Knapp, Anjene Musick, Joyce Tannenbaum, Catherine Te, William Eldridge, Shane Shapiro, Tiffany Musick, Colin Martin, Alistair So, Alyson Witt, Julian Blaschak Harvan, Richard M. Watanabe, William HagopianJohan Eriksson, Stella J. Nylund, Kimmo Kohtamaki, Eva Tuomilehto-Wolf, Liisa Toivanen, Gabriele Vidgren, Christian Ehnholm, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Michael Boehnke

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22 Scopus citations

Abstract

In the first reported positive result from a genome scan for non- insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of λ(s) (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score ≤ - 2) for λ(s) ≤ 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.

Original languageEnglish (US)
Pages (from-to)704-709
Number of pages6
JournalJournal of Clinical Investigation
Volume102
Issue number4
DOIs
StatePublished - Aug 15 1998

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Keywords

  • Affected sib-pairs
  • Fluorescent genotyping
  • Gene mapping
  • Linkage analysis
  • Non-insulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ghosh, S., Hauser, E. R., Magnuson, V. L., Valle, T., Ally, D. S., Karanjawala, Z. E., Rayman, J. B., Knapp, J. I., Musick, A., Tannenbaum, J., Te, C., Eldridge, W., Shapiro, S., Musick, T., Martin, C., So, A., Witt, A., Harvan, J. B., Watanabe, R. M., ... Boehnke, M. (1998). A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. Journal of Clinical Investigation, 102(4), 704-709. https://doi.org/10.1172/JCI2512