Abstract
We present a case of JC polyomavirus (JCV)-associated nephropathy (PyVAN) in an asymptomatic deceased-donor kidney transplant recipient. Despite the presence of viral cytopathic effect in the kidney biopsy and positive BK polyomavirus (BKV) in situ hybridization (ISH), BKV real-time polymerase chain reaction (PCR) results of plasma and urine were negative. JCV ISH was performed and was found to be positive. JCV real-time PCR on urine, plasma, and the kidney biopsy tissue was positive. Reduction in immunosuppression resulted in resolution of JCV viremia. This case highlights that JC-PyVAN is a distinct clinical entity and is likely to have a better clinical outcome than BK-PyVAN. Concurrent infection with BKV and JCV may occur, but may be difficult to confirm due to the potential for cross-reactivity between BKV and JCV ISH stains.
Original language | English (US) |
---|---|
Article number | e12646 |
Journal | Transplant Infectious Disease |
Volume | 19 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2017 |
Keywords
- BK virus
- JC virus
- nephropathy
- polyomavirus
ASJC Scopus subject areas
- Infectious Diseases
- Transplantation