A kidney transplant recipient with renal medullary viral cytopathic changes

Poornima Ramanan, Elizabeth A. Timmerman, Mary E. Fidler, Hatem Amer, Bobbi S. Pritt, Dale A. Schwab, Hollis J. Batterman, Matthew J. Binnicker

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We present a case of JC polyomavirus (JCV)-associated nephropathy (PyVAN) in an asymptomatic deceased-donor kidney transplant recipient. Despite the presence of viral cytopathic effect in the kidney biopsy and positive BK polyomavirus (BKV) in situ hybridization (ISH), BKV real-time polymerase chain reaction (PCR) results of plasma and urine were negative. JCV ISH was performed and was found to be positive. JCV real-time PCR on urine, plasma, and the kidney biopsy tissue was positive. Reduction in immunosuppression resulted in resolution of JCV viremia. This case highlights that JC-PyVAN is a distinct clinical entity and is likely to have a better clinical outcome than BK-PyVAN. Concurrent infection with BKV and JCV may occur, but may be difficult to confirm due to the potential for cross-reactivity between BKV and JCV ISH stains.

Original languageEnglish (US)
Article numbere12646
JournalTransplant Infectious Disease
Volume19
Issue number1
DOIs
StatePublished - Feb 1 2017

Fingerprint

JC Virus
BK Virus
Kidney
In Situ Hybridization
Real-Time Polymerase Chain Reaction
Viral Cytopathogenic Effect
Urine
Biopsy
Viremia
Immunosuppression
Transplant Recipients
Coloring Agents
Tissue Donors
Infection

Keywords

  • BK virus
  • JC virus
  • nephropathy
  • polyomavirus

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Ramanan, P., Timmerman, E. A., Fidler, M. E., Amer, H., Pritt, B. S., Schwab, D. A., ... Binnicker, M. J. (2017). A kidney transplant recipient with renal medullary viral cytopathic changes. Transplant Infectious Disease, 19(1), [e12646]. https://doi.org/10.1111/tid.12646

A kidney transplant recipient with renal medullary viral cytopathic changes. / Ramanan, Poornima; Timmerman, Elizabeth A.; Fidler, Mary E.; Amer, Hatem; Pritt, Bobbi S.; Schwab, Dale A.; Batterman, Hollis J.; Binnicker, Matthew J.

In: Transplant Infectious Disease, Vol. 19, No. 1, e12646, 01.02.2017.

Research output: Contribution to journalArticle

Ramanan, P, Timmerman, EA, Fidler, ME, Amer, H, Pritt, BS, Schwab, DA, Batterman, HJ & Binnicker, MJ 2017, 'A kidney transplant recipient with renal medullary viral cytopathic changes', Transplant Infectious Disease, vol. 19, no. 1, e12646. https://doi.org/10.1111/tid.12646
Ramanan P, Timmerman EA, Fidler ME, Amer H, Pritt BS, Schwab DA et al. A kidney transplant recipient with renal medullary viral cytopathic changes. Transplant Infectious Disease. 2017 Feb 1;19(1). e12646. https://doi.org/10.1111/tid.12646
Ramanan, Poornima ; Timmerman, Elizabeth A. ; Fidler, Mary E. ; Amer, Hatem ; Pritt, Bobbi S. ; Schwab, Dale A. ; Batterman, Hollis J. ; Binnicker, Matthew J. / A kidney transplant recipient with renal medullary viral cytopathic changes. In: Transplant Infectious Disease. 2017 ; Vol. 19, No. 1.
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