A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: Possible relevance of up-regulation of endothelial NO synthase mRNA

Hatsuyo Kano, Toshio Hayashi, Daigo Sumi, Teiji Esaki, Yukako Asai, Navin Kumar Thakur, Muthuvel Jayachandran, Akihisa Iguchi

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

We determined the role of Fluvastatin: HMG-CoA reductase inhibitor on the regression of atherosclerosis following removal of dietary cholesterol. Male rabbits fed a 0.5% cholesterol diet for 12 weeks were divided into three groups: A1, hypercholesterolemic; A2, fed a regular diet for an 12 additional weeks; and A3, fed a regular diet with fluvastatin (2 mg/kg/day). Fluvastatin treatment (A3) did not affect serum lipid levels compared with A2. However, it decreased the atherosclerotic area in the aortic arch and decreased total and esterified cholesterol concentrations in the descending aorta. Tone-related basal NO release in the thoracic aorta was larger in A3 than in A2. eNOS mRNA in vessel was determined by competitive RT-PCR assay. It increased in A1, compared with normal aorta and decreased in A2; however, it did not decrease in A3. This is the first report of a decrease in eNOS mRNA in atherosclerosis after removal of dietary cholesterol and a reversal of it by a HMG-CoA reductase inhibitor, which may contribute to the regression of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)414-419
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume259
Issue number2
DOIs
StatePublished - Jun 7 1999

Keywords

  • Arteriosclerosis
  • Endothelial nitric oxide synthase mRNA
  • Hypercholesterolemia
  • Nitric oxide
  • Regression

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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