A history of the use of anticonvulsants as mood stabilizers in the last two decades of the 20th century

R. M. Post, K. D. Denicoff, M. A. Frye, R. T. Dunn, G. S. Leverich, E. Osuch, A. Speer

Research output: Contribution to journalArticle

82 Scopus citations


Anticonvulsants have moved into an important position as alternatives and adjuncts to lithium carbonate in the treatment of bipolar illness. Work with the nonhomologous model of kindled seizures helped in the choice of carbamazepine as a potential mood stabilizer and in the study of the mechanisms of action of the second generation anticonvulsants carbamazepine and valproate, as well as the putative third generation psychotropic anticonvulsants lamotrigine and gabapentin. Anticonvulsant neuropeptides such as TRH and nonconvulsant approaches with repeated transcranial magnetic stimulation (rTMS) also appear promising.

Original languageEnglish (US)
Pages (from-to)152-166
Number of pages15
Issue number3
StatePublished - Oct 1 1998



  • Bipolar illness
  • Lithium
  • Mania
  • Refractory depression

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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