A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis

Zoe D. Daniil, Frances C. Gilchrist, Andrew G. Nicholson, David M. Hansell, Jessica Harris, Thomas V. Colby, Roland M. Du Bois

Research output: Contribution to journalArticle

354 Citations (Scopus)

Abstract

This study aimed to investigate whether there was a difference in outcome related to histologic pattern in cryptogenic fibrosing alveolitis (CFA) and to see whether there were correlations between clinical and radiologic findings and histology. One hundred thirteen lung biopsies from consecutive patients taken for the diagnosis of diffuse lung disease were reviewed and reclassified using the Katzenstein and Myers criteria for interstitial pneumonias. Patients lacking full investigational data at presentation and those with conditions predisposing to lung fibrosis were excluded, leaving 15 patients diagnosed with nonspecific interstitial pneumonia (NSIP) and 15 with usual interstitial pneumonia (UIP). Clinical and radiologic findings at presentation and serial lung function information and survival status in November 1998 were compared for the two groups. Survival was found to be significantly greater in the NSIP group compared with the UIP group (p < 0.001). This could not be explained by differences in treatment. Patients with UIP showed a progressive deterioration in lung function whereas those with NSIP remained stable. CT scans of patients with UIP showed more fibrosis than those of patients with NSIP (p < 0.011). A histologic diagnosis of NSIP is associated with a better prognosis than UIP. This subclassification of CFA is clinically useful.

Original languageEnglish (US)
Pages (from-to)899-905
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume160
Issue number3
StatePublished - 1999
Externally publishedYes

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Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases
Lung
Fibrosis
Survival
Lung Diseases
Histology
Biopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. / Daniil, Zoe D.; Gilchrist, Frances C.; Nicholson, Andrew G.; Hansell, David M.; Harris, Jessica; Colby, Thomas V.; Du Bois, Roland M.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 160, No. 3, 1999, p. 899-905.

Research output: Contribution to journalArticle

Daniil, Zoe D. ; Gilchrist, Frances C. ; Nicholson, Andrew G. ; Hansell, David M. ; Harris, Jessica ; Colby, Thomas V. ; Du Bois, Roland M. / A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. In: American Journal of Respiratory and Critical Care Medicine. 1999 ; Vol. 160, No. 3. pp. 899-905.
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