A high-pressure situation

Matthew J. Miller, M. John Hicks, Rod Foroozan, Michael C. Brodsky

Research output: Contribution to journalArticlepeer-review


An 8-year-old boy presented with acute visual loss in the right eye and nausea, vomiting, and diplopia. Imaging revealed a right orbital apex mass. Biopsy showed Langerhans cell histiocytosis (LCH), and the patient was diagnosed with isolated orbital LCH causing an orbital apex syndrome. A 12-month cytarabine chemotherapy course was begun, during which the patient developed bilateral optic disc edema. He was diagnosed with cytarabine-induced intracranial hypertension, which was successfully treated with acetazolamide. The cytarabine course was completed with complete resolution of the LCH lesion. The ophthalmologic relevance of this rare disorder is discussed.

Original languageEnglish (US)
JournalSurvey of ophthalmology
StateAccepted/In press - 2023


  • Cytarabine
  • Intracranial hypertension
  • Langerhans cell histiocytosis (LCH)
  • Orbital apex syndrome

ASJC Scopus subject areas

  • Ophthalmology


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