A hand-held beta imaging probe for FDG

Bipin Singh, Brendan C. Stack, Samta Thacker, Valeriy Gaysinskiy, Twyla Bartel, Val Lowe, Steven Cool, Gerald Entine, Vivek Nagarkar

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as 18FDG, 131I and 32P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. Methods: We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of 18FDG-avid primary tumors and metastases in an animal model. Results: We have demonstrated a device which can generate beta images from 18FDG avid lesions in an animal model. Conclusions: It is feasible to image beta irradiation in animal models of cancer given 18FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalAnnals of Nuclear Medicine
Volume27
Issue number3
DOIs
StatePublished - Apr 2013

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Fluorodeoxyglucose F18
Hand
Radiopharmaceuticals
Animal Models
Neoplasms
Neoplasm Metastasis
Equipment and Supplies
Operating Rooms
Technology

Keywords

  • I
  • FDG
  • Beta probe
  • Imaging
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Singh, B., Stack, B. C., Thacker, S., Gaysinskiy, V., Bartel, T., Lowe, V., ... Nagarkar, V. (2013). A hand-held beta imaging probe for FDG. Annals of Nuclear Medicine, 27(3), 203-208. https://doi.org/10.1007/s12149-012-0672-6

A hand-held beta imaging probe for FDG. / Singh, Bipin; Stack, Brendan C.; Thacker, Samta; Gaysinskiy, Valeriy; Bartel, Twyla; Lowe, Val; Cool, Steven; Entine, Gerald; Nagarkar, Vivek.

In: Annals of Nuclear Medicine, Vol. 27, No. 3, 04.2013, p. 203-208.

Research output: Contribution to journalArticle

Singh, B, Stack, BC, Thacker, S, Gaysinskiy, V, Bartel, T, Lowe, V, Cool, S, Entine, G & Nagarkar, V 2013, 'A hand-held beta imaging probe for FDG', Annals of Nuclear Medicine, vol. 27, no. 3, pp. 203-208. https://doi.org/10.1007/s12149-012-0672-6
Singh B, Stack BC, Thacker S, Gaysinskiy V, Bartel T, Lowe V et al. A hand-held beta imaging probe for FDG. Annals of Nuclear Medicine. 2013 Apr;27(3):203-208. https://doi.org/10.1007/s12149-012-0672-6
Singh, Bipin ; Stack, Brendan C. ; Thacker, Samta ; Gaysinskiy, Valeriy ; Bartel, Twyla ; Lowe, Val ; Cool, Steven ; Entine, Gerald ; Nagarkar, Vivek. / A hand-held beta imaging probe for FDG. In: Annals of Nuclear Medicine. 2013 ; Vol. 27, No. 3. pp. 203-208.
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