A hand-held beta imaging probe for FDG

Bipin Singh, Brendan C. Stack, Samta Thacker, Valeriy Gaysinskiy, Twyla Bartel, Val Lowe, Steven Cool, Gerald Entine, Vivek Nagarkar

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objectives: Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as 18FDG, 131I and 32P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. Methods: We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of 18FDG-avid primary tumors and metastases in an animal model. Results: We have demonstrated a device which can generate beta images from 18FDG avid lesions in an animal model. Conclusions: It is feasible to image beta irradiation in animal models of cancer given 18FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalAnnals of Nuclear Medicine
Volume27
Issue number3
DOIs
StatePublished - Apr 2013

Keywords

  • Beta probe
  • FDG
  • I
  • Imaging
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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