A genome-wide search for susceptibility genes linked to alcohol dependence

L. E. Peterson, J. S. Barnholtz, G. P. Page, T. M. King, M. De Andrade, C. I. Amos

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We performed two-point linkage analysis during a genome-wide search for susceptibility genes that predispose to alcohol dependence with the Collaborative Study on the Genetics on Alcoholism (COGA) data made available for the Genetic Analysis Workshop 11 (GAW11). For chromosomes I and 4 our findings supported results reported by Reich et al. [1998] based on the same data. We found similarity between our findings in regions on chromosomes 8 and 10 and reported results for schizophrenia linkage studies. Differences between our results with COGA data and those obtained by Reich et al. [1998] are due to our use of a lod score method versus their use of the affected relative pair (sib pair) method.

Original languageEnglish (US)
Pages (from-to)S295-S300
JournalGenetic epidemiology
Volume17
Issue numberSUPPL. 1
DOIs
StatePublished - 1999

Keywords

  • Alcoholism
  • Genetic linkage analysis

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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  • Cite this

    Peterson, L. E., Barnholtz, J. S., Page, G. P., King, T. M., De Andrade, M., & Amos, C. I. (1999). A genome-wide search for susceptibility genes linked to alcohol dependence. Genetic epidemiology, 17(SUPPL. 1), S295-S300. https://doi.org/10.1002/gepi.1370170750