A genome-wide scan for urinary albumin excretion in hypertensive families

Barry I. Freedman, Stephanie R. Beck, Stephen S. Rich, Gerardo Heiss, Cora E. Lewis, Stephen T Turner, Michael A. Province, Karen L. Schwander, Donna K. Arnett, Beverly G. Mellen

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Albuminuria increases the risk of cardiovascular events in patients with essential hypertension and diabetic subjects. The heritability (h2) of albuminuria in multiplex hypertensive families is unknown. We calculated the familial aggregation of urine albumin: creatinine ratio (ACR) and performed a genome-wide scan to assess for loci contributing to ACR in participants enrolled in the Hypertension Genetic Epidemiology Network (HyperGEN). To perform the genome scan, we analyzed genotype results from 2589 individuals from 805 families in the Family Blood Pressure Program. ACR and covariates were available in 1727 individuals (mean age, 57.1 years). Estimates of h 2 were obtained by using variance component methodology as implemented in the SOLAR software package. Linkage was tested between 387 markers spanning the genome at an average interval of 9.32 cM, using SOLAR multipoint analysis. The h2 of log urine ACR was 0.49 (P<1 × 10-7) after controlling for significant main and interactive effects of age, gender, race, body mass index, blood pressure, and use of ACE inhibitors or angiotensin-2 receptor blockers. The genome-wide scan revealed a maximum LOD score of 2.73 on chromosome 19 (robust corrected LOD, 2.40; P=0.0009) at marker D19S591 and a LOD score of 2.0 on chromosome 12 (robust corrected LOD, 1.75; P=0.005) at marker PAH. These analyses demonstrate the marked heritability of urine ACR in families enriched for the presence of members with essential hypertension. They suggest that a gene(s) associated with urinary ACR may be present on human chromosomes. 19 and 12.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalHypertension
Volume42
Issue number3
DOIs
StatePublished - Sep 1 2003

Fingerprint

Albumins
Creatinine
Genome
Albuminuria
Urine
Blood Pressure
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 12
Molecular Epidemiology
Angiotensin Receptor Antagonists
Human Chromosomes
Angiotensin-Converting Enzyme Inhibitors
Body Mass Index
Software
Genotype
Hypertension
Genes
Essential Hypertension

Keywords

  • Albuminuria
  • Blacks
  • Hypertension, essential
  • Nephrosclerosis
  • Race

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Freedman, B. I., Beck, S. R., Rich, S. S., Heiss, G., Lewis, C. E., Turner, S. T., ... Mellen, B. G. (2003). A genome-wide scan for urinary albumin excretion in hypertensive families. Hypertension, 42(3), 291-296. https://doi.org/10.1161/01.HYP.0000087890.33245.41

A genome-wide scan for urinary albumin excretion in hypertensive families. / Freedman, Barry I.; Beck, Stephanie R.; Rich, Stephen S.; Heiss, Gerardo; Lewis, Cora E.; Turner, Stephen T; Province, Michael A.; Schwander, Karen L.; Arnett, Donna K.; Mellen, Beverly G.

In: Hypertension, Vol. 42, No. 3, 01.09.2003, p. 291-296.

Research output: Contribution to journalArticle

Freedman, BI, Beck, SR, Rich, SS, Heiss, G, Lewis, CE, Turner, ST, Province, MA, Schwander, KL, Arnett, DK & Mellen, BG 2003, 'A genome-wide scan for urinary albumin excretion in hypertensive families', Hypertension, vol. 42, no. 3, pp. 291-296. https://doi.org/10.1161/01.HYP.0000087890.33245.41
Freedman, Barry I. ; Beck, Stephanie R. ; Rich, Stephen S. ; Heiss, Gerardo ; Lewis, Cora E. ; Turner, Stephen T ; Province, Michael A. ; Schwander, Karen L. ; Arnett, Donna K. ; Mellen, Beverly G. / A genome-wide scan for urinary albumin excretion in hypertensive families. In: Hypertension. 2003 ; Vol. 42, No. 3. pp. 291-296.
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AU - Turner, Stephen T

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