A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai, Zhaoming Wang, Sonja I. Berndt, Christine F. Skibola, Susan L Slager, Silvia De Sanjose, Mads Melbye, Bengt Glimelius, Paige M. Bracci, Lucia Conde, Brenda M. Birmann, Sophia S. Wang, Angela R. Brooks-Wilson, Qing Lan, Paul I W De Bakker, Roel C H Vermeulen, Carol Portlock, Stephen Maxted Ansell, Brian K. Link, Jacques RibyKari E. North, Jian Gu, Henrik Hjalgrim, Wendy Cozen, Nikolaus Becker, Lauren R. Teras, John J. Spinelli, Jenny Turner, Yawei Zhang, Mark P. Purdue, Graham G. Giles, Rachel S. Kelly, Anne Zeleniuch-Jacquotte, Maria Grazia Ennas, Alain Monnereau, Kimberly A. Bertrand, Demetrius Albanes, Tracy Lightfoot, Meredith Yeager, Charles C. Chung, Laurie Burdett, Amy Hutchinson, Charles Lawrence, Rebecca Montalvan, Liming Liang, Jinyan Huang, Baoshan Ma, Danylo J. Villano, Ann Maria, Marina Corines, Tinu Thomas, Anne J Novak, Ahmet Dogan, Mark Liebow, Carrie A Thompson, Thomas Elmer Witzig, Thomas Matthew Habermann, George J. Weiner, Martyn T. Smith, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yuanqing Ye, Hans Olov Adami, Karin E. Smedby, Anneclaire J. De Roos, Patricia Hartge, Lindsay M. Morton, Richard K. Severson, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, W. Ryan DIver, Claire M. Vajdic, Bruce K. Armstrong, Anne Kricker, Tongzhang Zheng, Theodore R. Holford, Gianluca Severi, Paolo Vineis, Giovanni M. Ferri, Rosalia Ricco, Lucia Miligi, Jacqueline Clavel, Edward Giovannucci, Peter Kraft, Jarmo Virtamo, Alex Smith, Eleanor Kane, Eve Roman, Brian C H Chiu, Joseph F. Fraumeni, Xifeng Wu, James R Cerhan, Kenneth Offit, Stephen J. Chanock, Nathaniel Rothman, Alexandra Nieters

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10 '15) and HLA-B (rs2922994, P=2.43 × 10 '9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Original languageEnglish (US)
Article number6751
JournalNature Communications
Volume6
DOIs
StatePublished - Jan 8 2015

Fingerprint

HLA-B Antigens
genome
Genome-Wide Association Study
loci
Lymphoma
Genes
Cells
magnetic permeability
B-Cell Lymphoma
Major Histocompatibility Complex
Non-Hodgkin's Lymphoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

A genome-wide association study of marginal zone lymphoma shows association to the HLA region. / Vijai, Joseph; Wang, Zhaoming; Berndt, Sonja I.; Skibola, Christine F.; Slager, Susan L; De Sanjose, Silvia; Melbye, Mads; Glimelius, Bengt; Bracci, Paige M.; Conde, Lucia; Birmann, Brenda M.; Wang, Sophia S.; Brooks-Wilson, Angela R.; Lan, Qing; De Bakker, Paul I W; Vermeulen, Roel C H; Portlock, Carol; Ansell, Stephen Maxted; Link, Brian K.; Riby, Jacques; North, Kari E.; Gu, Jian; Hjalgrim, Henrik; Cozen, Wendy; Becker, Nikolaus; Teras, Lauren R.; Spinelli, John J.; Turner, Jenny; Zhang, Yawei; Purdue, Mark P.; Giles, Graham G.; Kelly, Rachel S.; Zeleniuch-Jacquotte, Anne; Ennas, Maria Grazia; Monnereau, Alain; Bertrand, Kimberly A.; Albanes, Demetrius; Lightfoot, Tracy; Yeager, Meredith; Chung, Charles C.; Burdett, Laurie; Hutchinson, Amy; Lawrence, Charles; Montalvan, Rebecca; Liang, Liming; Huang, Jinyan; Ma, Baoshan; Villano, Danylo J.; Maria, Ann; Corines, Marina; Thomas, Tinu; Novak, Anne J; Dogan, Ahmet; Liebow, Mark; Thompson, Carrie A; Witzig, Thomas Elmer; Habermann, Thomas Matthew; Weiner, George J.; Smith, Martyn T.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Ye, Yuanqing; Adami, Hans Olov; Smedby, Karin E.; De Roos, Anneclaire J.; Hartge, Patricia; Morton, Lindsay M.; Severson, Richard K.; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; DIver, W. Ryan; Vajdic, Claire M.; Armstrong, Bruce K.; Kricker, Anne; Zheng, Tongzhang; Holford, Theodore R.; Severi, Gianluca; Vineis, Paolo; Ferri, Giovanni M.; Ricco, Rosalia; Miligi, Lucia; Clavel, Jacqueline; Giovannucci, Edward; Kraft, Peter; Virtamo, Jarmo; Smith, Alex; Kane, Eleanor; Roman, Eve; Chiu, Brian C H; Fraumeni, Joseph F.; Wu, Xifeng; Cerhan, James R; Offit, Kenneth; Chanock, Stephen J.; Rothman, Nathaniel; Nieters, Alexandra.

In: Nature Communications, Vol. 6, 6751, 08.01.2015.

Research output: Contribution to journalArticle

Vijai, J, Wang, Z, Berndt, SI, Skibola, CF, Slager, SL, De Sanjose, S, Melbye, M, Glimelius, B, Bracci, PM, Conde, L, Birmann, BM, Wang, SS, Brooks-Wilson, AR, Lan, Q, De Bakker, PIW, Vermeulen, RCH, Portlock, C, Ansell, SM, Link, BK, Riby, J, North, KE, Gu, J, Hjalgrim, H, Cozen, W, Becker, N, Teras, LR, Spinelli, JJ, Turner, J, Zhang, Y, Purdue, MP, Giles, GG, Kelly, RS, Zeleniuch-Jacquotte, A, Ennas, MG, Monnereau, A, Bertrand, KA, Albanes, D, Lightfoot, T, Yeager, M, Chung, CC, Burdett, L, Hutchinson, A, Lawrence, C, Montalvan, R, Liang, L, Huang, J, Ma, B, Villano, DJ, Maria, A, Corines, M, Thomas, T, Novak, AJ, Dogan, A, Liebow, M, Thompson, CA, Witzig, TE, Habermann, TM, Weiner, GJ, Smith, MT, Holly, EA, Jackson, RD, Tinker, LF, Ye, Y, Adami, HO, Smedby, KE, De Roos, AJ, Hartge, P, Morton, LM, Severson, RK, Benavente, Y, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, DIver, WR, Vajdic, CM, Armstrong, BK, Kricker, A, Zheng, T, Holford, TR, Severi, G, Vineis, P, Ferri, GM, Ricco, R, Miligi, L, Clavel, J, Giovannucci, E, Kraft, P, Virtamo, J, Smith, A, Kane, E, Roman, E, Chiu, BCH, Fraumeni, JF, Wu, X, Cerhan, JR, Offit, K, Chanock, SJ, Rothman, N & Nieters, A 2015, 'A genome-wide association study of marginal zone lymphoma shows association to the HLA region', Nature Communications, vol. 6, 6751. https://doi.org/10.1038/ncomms6751
Vijai, Joseph ; Wang, Zhaoming ; Berndt, Sonja I. ; Skibola, Christine F. ; Slager, Susan L ; De Sanjose, Silvia ; Melbye, Mads ; Glimelius, Bengt ; Bracci, Paige M. ; Conde, Lucia ; Birmann, Brenda M. ; Wang, Sophia S. ; Brooks-Wilson, Angela R. ; Lan, Qing ; De Bakker, Paul I W ; Vermeulen, Roel C H ; Portlock, Carol ; Ansell, Stephen Maxted ; Link, Brian K. ; Riby, Jacques ; North, Kari E. ; Gu, Jian ; Hjalgrim, Henrik ; Cozen, Wendy ; Becker, Nikolaus ; Teras, Lauren R. ; Spinelli, John J. ; Turner, Jenny ; Zhang, Yawei ; Purdue, Mark P. ; Giles, Graham G. ; Kelly, Rachel S. ; Zeleniuch-Jacquotte, Anne ; Ennas, Maria Grazia ; Monnereau, Alain ; Bertrand, Kimberly A. ; Albanes, Demetrius ; Lightfoot, Tracy ; Yeager, Meredith ; Chung, Charles C. ; Burdett, Laurie ; Hutchinson, Amy ; Lawrence, Charles ; Montalvan, Rebecca ; Liang, Liming ; Huang, Jinyan ; Ma, Baoshan ; Villano, Danylo J. ; Maria, Ann ; Corines, Marina ; Thomas, Tinu ; Novak, Anne J ; Dogan, Ahmet ; Liebow, Mark ; Thompson, Carrie A ; Witzig, Thomas Elmer ; Habermann, Thomas Matthew ; Weiner, George J. ; Smith, Martyn T. ; Holly, Elizabeth A. ; Jackson, Rebecca D. ; Tinker, Lesley F. ; Ye, Yuanqing ; Adami, Hans Olov ; Smedby, Karin E. ; De Roos, Anneclaire J. ; Hartge, Patricia ; Morton, Lindsay M. ; Severson, Richard K. ; Benavente, Yolanda ; Boffetta, Paolo ; Brennan, Paul ; Foretova, Lenka ; Maynadie, Marc ; McKay, James ; Staines, Anthony ; DIver, W. Ryan ; Vajdic, Claire M. ; Armstrong, Bruce K. ; Kricker, Anne ; Zheng, Tongzhang ; Holford, Theodore R. ; Severi, Gianluca ; Vineis, Paolo ; Ferri, Giovanni M. ; Ricco, Rosalia ; Miligi, Lucia ; Clavel, Jacqueline ; Giovannucci, Edward ; Kraft, Peter ; Virtamo, Jarmo ; Smith, Alex ; Kane, Eleanor ; Roman, Eve ; Chiu, Brian C H ; Fraumeni, Joseph F. ; Wu, Xifeng ; Cerhan, James R ; Offit, Kenneth ; Chanock, Stephen J. ; Rothman, Nathaniel ; Nieters, Alexandra. / A genome-wide association study of marginal zone lymphoma shows association to the HLA region. In: Nature Communications. 2015 ; Vol. 6.
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AU - De Sanjose, Silvia

AU - Melbye, Mads

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AU - North, Kari E.

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AU - Vajdic, Claire M.

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AU - Giovannucci, Edward

AU - Kraft, Peter

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AU - Smith, Alex

AU - Kane, Eleanor

AU - Roman, Eve

AU - Chiu, Brian C H

AU - Fraumeni, Joseph F.

AU - Wu, Xifeng

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