TY - JOUR
T1 - A GENE MAPPING BETWEEN THE S AND D REGIONS OF THE H‐2 COMPLEX INFLUENCES RESISTANCE TO TRICHINELLA SPIRALIS INFECTIONS OF MICE
AU - Wassom, D. L.
AU - Brooks, B. O.
AU - Babish, J. G.
AU - David, C. S.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1983/10
Y1 - 1983/10
N2 - The strains B 10.S(7R), B 10.S(23 R) and B 10.S(24R), all thought to be genetically identical, differ in levels of susceptibility to infection with Trichinella spiralis. In a series of nine independent experiments, B 10.S(7R) was shown to be more susceptible than the other two strains. In another series of seven experiments, the strain B 10.A(18R) was shown to be more susceptible to infection with T. spiralis than the strains B 10.S(21R) or B 10.BAR‐5, all of which were thought to share common H‐2 alleles. These results indicate that a gene mapping between the S and D loci influences susceptibility to infection with T. spiralis. Typing of these strains for Qa and Tl loci rule out the possibility of a double crossover accounting for the differences observed. The new gene is designated Ts‐2. Previously published data have also been reinterpreted and another gene Ts‐1 is shown to be associated with the Aβ locus. When the d allele is expressed at the Ts‐2 locus, strains of mice expressing s, q, f or b alleles at Ts‐1 are rendered more susceptible to infection.
AB - The strains B 10.S(7R), B 10.S(23 R) and B 10.S(24R), all thought to be genetically identical, differ in levels of susceptibility to infection with Trichinella spiralis. In a series of nine independent experiments, B 10.S(7R) was shown to be more susceptible than the other two strains. In another series of seven experiments, the strain B 10.A(18R) was shown to be more susceptible to infection with T. spiralis than the strains B 10.S(21R) or B 10.BAR‐5, all of which were thought to share common H‐2 alleles. These results indicate that a gene mapping between the S and D loci influences susceptibility to infection with T. spiralis. Typing of these strains for Qa and Tl loci rule out the possibility of a double crossover accounting for the differences observed. The new gene is designated Ts‐2. Previously published data have also been reinterpreted and another gene Ts‐1 is shown to be associated with the Aβ locus. When the d allele is expressed at the Ts‐2 locus, strains of mice expressing s, q, f or b alleles at Ts‐1 are rendered more susceptible to infection.
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U2 - 10.1111/j.1744-313X.1983.tb00349.x
DO - 10.1111/j.1744-313X.1983.tb00349.x
M3 - Article
C2 - 6417245
AN - SCOPUS:0021043201
SN - 1744-3121
VL - 10
SP - 371
EP - 378
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
IS - 5
ER -