A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder

George Kirov, Nadine Norton, Ian Jones, Fiona McCandless, Nick Craddock, Michael J. Owen

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The genes encoding for the enzymes monoamine oxidase (MAO) A and B are good candidates to investigate bipolar affective disorder. A 30 bp repeat in the MAOA promoter was recently demonstrated to be polymorphic and to affect transcriptional activity. In a family-based association design we found that none of the different repeat copies was preferentially transmitted from mothers (n = 131) to their children affected with bipolar disorder (χ2 = 2.75, 4 d.f., p = 0.6). Following on our previous finding of an excess of low-activity genotypes of catechol-O-methyltransferase in patients with a rapid cycling form of illness, we examined for a similar trend with MAOA alleles. In an extended sample we found a non-significant trend for patients with an ultra-rapid cycling form of illness (n = 29) to have a higher frequency of low-activity alleles compared with 92 bipolar patients with a non-rapid cycling course of illness (χ2 = 2.37, 1 d.f., p = 0.13).

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Volume2
Issue number4
DOIs
StatePublished - Dec 1999

Keywords

  • Bipolar
  • Genetic
  • MAOA
  • MAOB
  • Rapid cycling

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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