A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder

George Kirov, Nadine Norton, Ian Jones, Fiona McCandless, Nick Craddock, Michael J. Owen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The genes encoding for the enzymes monoamine oxidase (MAO) A and B are good candidates to investigate bipolar affective disorder. A 30 bp repeat in the MAOA promoter was recently demonstrated to be polymorphic and to affect transcriptional activity. In a family-based association design we found that none of the different repeat copies was preferentially transmitted from mothers (n = 131) to their children affected with bipolar disorder (χ2 = 2.75, 4 d.f., p = 0.6). Following on our previous finding of an excess of low-activity genotypes of catechol-O-methyltransferase in patients with a rapid cycling form of illness, we examined for a similar trend with MAOA alleles. In an extended sample we found a non-significant trend for patients with an ultra-rapid cycling form of illness (n = 29) to have a higher frequency of low-activity alleles compared with 92 bipolar patients with a non-rapid cycling course of illness (χ2 = 2.37, 1 d.f., p = 0.13).

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Volume2
Issue number4
StatePublished - Dec 1999
Externally publishedYes

Fingerprint

Monoamine Oxidase
Mood Disorders
Bipolar Disorder
Alleles
Genes
Catechol O-Methyltransferase
Genotype
Mothers
Enzymes

Keywords

  • Bipolar
  • Genetic
  • MAOA
  • MAOB
  • Rapid cycling

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology

Cite this

A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder. / Kirov, George; Norton, Nadine; Jones, Ian; McCandless, Fiona; Craddock, Nick; Owen, Michael J.

In: International Journal of Neuropsychopharmacology, Vol. 2, No. 4, 12.1999, p. 293-298.

Research output: Contribution to journalArticle

Kirov, George ; Norton, Nadine ; Jones, Ian ; McCandless, Fiona ; Craddock, Nick ; Owen, Michael J. / A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder. In: International Journal of Neuropsychopharmacology. 1999 ; Vol. 2, No. 4. pp. 293-298.
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