A Framework for Evidence Synthesis Programs to Respond to a Pandemic

M. Hassan Murad, Tarek Nayfeh, Meritxell Urtecho Suarez, Mohamed O. Seisa, Rami Abd-Rabu, Magdoleen Hassan Eltayeb Farah, Mohammed Firwana, Bashar Hasan, Tabinda Jawaid, Sahrish Shah, Victor Torres Roldan, Larry Prokop, Zhen Wang, Samer Mohir Saadi

Research output: Contribution to journalArticle


The coronavirus disease 2019 (COVID-19) pandemic requires making rapid decisions based on sparse and rapidly changing evidence. Evidence synthesis programs conduct systematic reviews for guideline developers, health systems clinicians, and decision-makers that usually take an average 6 to 8 months to complete. We present a framework for evidence synthesis programs to respond to pandemics that has proven feasible and practical during the COVID-19 response in a large multistate health system employing more than 78,000 people. The framework includes four components: an approach for conducting rapid reviews, a repository of rapid reviews, a registry for all original studies about COVID-19, and twice-weekly prioritized update of new evidence sent to key stakeholders. As COVID-19 will not be our last pandemic, we share the details of this framework to allow replication in other institutions and re-implementation in future pandemics.

Original languageEnglish (US)
Pages (from-to)1426-1429
Number of pages4
JournalMayo Clinic proceedings
Issue number7
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Medicine(all)

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    Murad, M. H., Nayfeh, T., Urtecho Suarez, M., Seisa, M. O., Abd-Rabu, R., Farah, M. H. E., Firwana, M., Hasan, B., Jawaid, T., Shah, S., Torres Roldan, V., Prokop, L., Wang, Z., & Saadi, S. M. (2020). A Framework for Evidence Synthesis Programs to Respond to a Pandemic. Mayo Clinic proceedings, 95(7), 1426-1429. https://doi.org/10.1016/j.mayocp.2020.05.009