{A figure is presented}Colorectal Cancer Risks in Relatives of Young-Onset Cases

Is Risk the Same Across All First-Degree Relatives?

Lisa Allyn Boardman, Bruce W. Morlan, Kari G. Rabe, Gloria M Petersen, Noralane Morey Lindor, Sandra K. Nigon, Julia Goldberg, Steven Gallinger

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background & Aims: During the last 15 years, several single-gene mendelian disorders have been discovered that might account for some of the familial aggregation detected in large population studies of colorectal cancer (CRC). Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer-Lynch syndrome, the most common of the recognized CRC-predisposition syndromes, in which one major feature is a young age for cancer onset. However, for young-onset microsatellite stable (MSS) CRC, the familial risk for CRC is unknown. Methods: Patients with CRC who were <50 years old were identified through Minnesota Cancer Surveillance System (MCSS) and Mayo Clinic, Rochester, MN. CRCs in which the DNA MMR function was deficient as evidenced by high level microsatellite instability and/or loss of expression of MMR gene product by immunostaining were excluded. A total of 278 probands (131 from MCSS; 147 from Mayo Clinic) were included. Data on 1862 relatives were collected, of whom 68 were found to have had CRC, and an additional 165 had primary cancers of other types. Results: Compared with Surveillance Epidemiology and End Results program data, relatives of young-onset CRC probands had increased risks for CRC. This relative risk (RR) was increased among first-degree relatives (RR, 1.65; 95% confidence interval [CI], 1.29-2.07) and was greater for siblings (RR, 2.67; 95% CI, 1.50-4.41) than parents (RR, 1.5; 95% CI, 1.14-1.94). Conclusions: We studied 278 probands with young-onset MSS CRC. We determined that the RR for CRC was greatest in siblings, which is consistent with an autosomal recessive inheritance pattern.

Original languageEnglish (US)
Pages (from-to)1195-1198
Number of pages4
JournalClinical Gastroenterology and Hepatology
Volume5
Issue number10
DOIs
StatePublished - Oct 2007

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Colorectal Neoplasms
DNA Mismatch Repair
Hereditary Nonpolyposis Colorectal Neoplasms
Confidence Intervals
Microsatellite Repeats
Siblings
Neoplasms
SEER Program
Genes
Inheritance Patterns
Microsatellite Instability
Age of Onset
Parents
Mutation
Population

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

{A figure is presented}Colorectal Cancer Risks in Relatives of Young-Onset Cases : Is Risk the Same Across All First-Degree Relatives? / Boardman, Lisa Allyn; Morlan, Bruce W.; Rabe, Kari G.; Petersen, Gloria M; Lindor, Noralane Morey; Nigon, Sandra K.; Goldberg, Julia; Gallinger, Steven.

In: Clinical Gastroenterology and Hepatology, Vol. 5, No. 10, 10.2007, p. 1195-1198.

Research output: Contribution to journalArticle

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title = "{A figure is presented}Colorectal Cancer Risks in Relatives of Young-Onset Cases: Is Risk the Same Across All First-Degree Relatives?",
abstract = "Background & Aims: During the last 15 years, several single-gene mendelian disorders have been discovered that might account for some of the familial aggregation detected in large population studies of colorectal cancer (CRC). Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer-Lynch syndrome, the most common of the recognized CRC-predisposition syndromes, in which one major feature is a young age for cancer onset. However, for young-onset microsatellite stable (MSS) CRC, the familial risk for CRC is unknown. Methods: Patients with CRC who were <50 years old were identified through Minnesota Cancer Surveillance System (MCSS) and Mayo Clinic, Rochester, MN. CRCs in which the DNA MMR function was deficient as evidenced by high level microsatellite instability and/or loss of expression of MMR gene product by immunostaining were excluded. A total of 278 probands (131 from MCSS; 147 from Mayo Clinic) were included. Data on 1862 relatives were collected, of whom 68 were found to have had CRC, and an additional 165 had primary cancers of other types. Results: Compared with Surveillance Epidemiology and End Results program data, relatives of young-onset CRC probands had increased risks for CRC. This relative risk (RR) was increased among first-degree relatives (RR, 1.65; 95{\%} confidence interval [CI], 1.29-2.07) and was greater for siblings (RR, 2.67; 95{\%} CI, 1.50-4.41) than parents (RR, 1.5; 95{\%} CI, 1.14-1.94). Conclusions: We studied 278 probands with young-onset MSS CRC. We determined that the RR for CRC was greatest in siblings, which is consistent with an autosomal recessive inheritance pattern.",
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T1 - {A figure is presented}Colorectal Cancer Risks in Relatives of Young-Onset Cases

T2 - Is Risk the Same Across All First-Degree Relatives?

AU - Boardman, Lisa Allyn

AU - Morlan, Bruce W.

AU - Rabe, Kari G.

AU - Petersen, Gloria M

AU - Lindor, Noralane Morey

AU - Nigon, Sandra K.

AU - Goldberg, Julia

AU - Gallinger, Steven

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N2 - Background & Aims: During the last 15 years, several single-gene mendelian disorders have been discovered that might account for some of the familial aggregation detected in large population studies of colorectal cancer (CRC). Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer-Lynch syndrome, the most common of the recognized CRC-predisposition syndromes, in which one major feature is a young age for cancer onset. However, for young-onset microsatellite stable (MSS) CRC, the familial risk for CRC is unknown. Methods: Patients with CRC who were <50 years old were identified through Minnesota Cancer Surveillance System (MCSS) and Mayo Clinic, Rochester, MN. CRCs in which the DNA MMR function was deficient as evidenced by high level microsatellite instability and/or loss of expression of MMR gene product by immunostaining were excluded. A total of 278 probands (131 from MCSS; 147 from Mayo Clinic) were included. Data on 1862 relatives were collected, of whom 68 were found to have had CRC, and an additional 165 had primary cancers of other types. Results: Compared with Surveillance Epidemiology and End Results program data, relatives of young-onset CRC probands had increased risks for CRC. This relative risk (RR) was increased among first-degree relatives (RR, 1.65; 95% confidence interval [CI], 1.29-2.07) and was greater for siblings (RR, 2.67; 95% CI, 1.50-4.41) than parents (RR, 1.5; 95% CI, 1.14-1.94). Conclusions: We studied 278 probands with young-onset MSS CRC. We determined that the RR for CRC was greatest in siblings, which is consistent with an autosomal recessive inheritance pattern.

AB - Background & Aims: During the last 15 years, several single-gene mendelian disorders have been discovered that might account for some of the familial aggregation detected in large population studies of colorectal cancer (CRC). Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer-Lynch syndrome, the most common of the recognized CRC-predisposition syndromes, in which one major feature is a young age for cancer onset. However, for young-onset microsatellite stable (MSS) CRC, the familial risk for CRC is unknown. Methods: Patients with CRC who were <50 years old were identified through Minnesota Cancer Surveillance System (MCSS) and Mayo Clinic, Rochester, MN. CRCs in which the DNA MMR function was deficient as evidenced by high level microsatellite instability and/or loss of expression of MMR gene product by immunostaining were excluded. A total of 278 probands (131 from MCSS; 147 from Mayo Clinic) were included. Data on 1862 relatives were collected, of whom 68 were found to have had CRC, and an additional 165 had primary cancers of other types. Results: Compared with Surveillance Epidemiology and End Results program data, relatives of young-onset CRC probands had increased risks for CRC. This relative risk (RR) was increased among first-degree relatives (RR, 1.65; 95% confidence interval [CI], 1.29-2.07) and was greater for siblings (RR, 2.67; 95% CI, 1.50-4.41) than parents (RR, 1.5; 95% CI, 1.14-1.94). Conclusions: We studied 278 probands with young-onset MSS CRC. We determined that the RR for CRC was greatest in siblings, which is consistent with an autosomal recessive inheritance pattern.

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