A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder

Darko Turic, Kate Langley, Hywel Williams, Nadine Norton, Nigel M. Williams, Valentina Moskvina, Marianne B. Van Den Bree, Michael J. Owen, Anita Thapar, Michael C. O'Donovan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: The glutamatergic system, the major excitatory neurotransmitter system in the central nervous system (CNS) has been proposed as contributing a possible role in the etiology of attention deficit hyperactivity disorder (ADHD). This is based upon observations from animal, neuroimaging, neuroanatomical and neuropsychological studies. Genes related to glutamate function are therefore good functional candidates for this disorder. The SLC1A3 (Solute Carrier Family 1, member 3) gene encodes a glial glutamate transporter which maps to chromosome 5p12, a region of linkage that coincides in two published ADHD genome scans so far. SLC1A3 is thus both a functional and positional candidate gene for ADHD. Methods: We have undertaken detailed association analysis of SLC1A3 using a multi-stage approach for candidate gene analysis. Results: In a family-based sample (n = 299) we found a significant association between marker rs2269272 (p = .007) and ADHD. Two, two-marker haplotypes, rs2269272/rs3776581 (p = .016) and rs2269272/rs2032893 (p = .013) also yielded evidence of association. Conclusions: The results of our study suggest that genetic variation in SLC1A3 may contribute to susceptibility to ADHD.

Original languageEnglish (US)
Pages (from-to)1461-1466
Number of pages6
JournalBiological psychiatry
Volume57
Issue number11
DOIs
StatePublished - Jun 1 2005

Keywords

  • Attention deficit hyperactivity disorder (ADHD)
  • Glutamate function
  • Haplotype
  • Polymorphisms
  • SLC1A3

ASJC Scopus subject areas

  • Biological Psychiatry

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    Turic, D., Langley, K., Williams, H., Norton, N., Williams, N. M., Moskvina, V., Van Den Bree, M. B., Owen, M. J., Thapar, A., & O'Donovan, M. C. (2005). A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry, 57(11), 1461-1466. https://doi.org/10.1016/j.biopsych.2005.03.025