A facile synthesis of [11C]acetylene

Rachid Nazih, Jeremy P. Blauser, Bruce H. Mock, Timothy R DeGrado

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acetylene is a versatile synthon organic chemistry. The complexity and difficulty of synthesis of [11C]acetylene has limited its use as a labeling intermediate for PET radiotracers. A new method for production of [11C]acetylene has been developed in our laboratory that simplifies the synthesis procedure allowing for easy automation and implementation. The technique is a modification of Madsen et al. (1981, Phys. Med. Biol. 26(5), 875) that utilized carbon dioxide (11C) and barium. First [ 11/12C]CO2 was trapped at room temperature on barium within a quartz reaction tube, then heated to 900°C under hydrogen flow to release [11C]acetylene. Hydrogen gas is apparently oxidized to form water vapor which reacts immediately with the formed carbide to liberate acetylene. Radiochemical yields of 31.4-75.4% and specific activities of 0.11-161 mCi/μmol have been obtained with radiochemical purities greater than 99%. This technique provides a new, efficient and very practical synthesis of [11C]acetylene that can be utilized as synthon for novel PET radiopharmaceuticals.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalApplied Radiation and Isotopes
Volume63
Issue number3
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

acetylene
synthesis
barium
organic chemistry
hydrogen
automation
carbides
marking
water vapor
carbon dioxide
purity
quartz
tubes
room temperature
gases

Keywords

  • [C]acetylene
  • Automation
  • Barium
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Radiation

Cite this

A facile synthesis of [11C]acetylene. / Nazih, Rachid; Blauser, Jeremy P.; Mock, Bruce H.; DeGrado, Timothy R.

In: Applied Radiation and Isotopes, Vol. 63, No. 3, 09.2005, p. 305-309.

Research output: Contribution to journalArticle

Nazih, Rachid ; Blauser, Jeremy P. ; Mock, Bruce H. ; DeGrado, Timothy R. / A facile synthesis of [11C]acetylene. In: Applied Radiation and Isotopes. 2005 ; Vol. 63, No. 3. pp. 305-309.
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