A dose-effect relationship of Ginkgo biloba extract to nerve regeneration in a rat model

Haodong Lin, Huan D Wang, Desong Chen, Yudong Gu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of Ginkgo biloba extract (EGb50) on nerve regeneration and its dose-effect relationship was investigated in a rat model. Sciatic nerve transection and repair was done in 120 Sprague-Dawley rats. The animals were divided into four groups and given normal saline, low-dose EGb 50 (50 mg kg-1 d-1), moderate-dose EGb 50 (100 mg kg-1 d-1), and high-dose EGb 50 (200 mg kg-1 d-1), respectively. Electrophysiological, histological examinations, and functional evaluation were conducted at various postoperative intervals. Sensory regeneration distance, sciatic functional index (SFI), motor nerve conduction velocity, compound muscle action potential, axon regeneration index, and muscle mass were significantly higher in EGb50 groups than in saline groups. All but SFI of those parameters were better in high-dose group when compared with those in moderate- and low-dose groups. EGb50 has the effect of promoting regeneration of injured peripheral nerve. The higher the dose, the better the result.

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalMicrosurgery
Volume27
Issue number8
DOIs
StatePublished - 2007
Externally publishedYes

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Ginkgo biloba
Nerve Regeneration
Regeneration
Muscles
Neural Conduction
Sciatic Nerve
Peripheral Nerves
Action Potentials
Sprague Dawley Rats
Axons

ASJC Scopus subject areas

  • Surgery

Cite this

A dose-effect relationship of Ginkgo biloba extract to nerve regeneration in a rat model. / Lin, Haodong; Wang, Huan D; Chen, Desong; Gu, Yudong.

In: Microsurgery, Vol. 27, No. 8, 2007, p. 673-677.

Research output: Contribution to journalArticle

Lin, Haodong ; Wang, Huan D ; Chen, Desong ; Gu, Yudong. / A dose-effect relationship of Ginkgo biloba extract to nerve regeneration in a rat model. In: Microsurgery. 2007 ; Vol. 27, No. 8. pp. 673-677.
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