A distinctive interaction between chronic anxiety and problem solving in asymptomatic APOE e4 homozygotes

Richard J. Caselli; Eric M. Reiman; Joseph G. Hentz; David Osborne; Gene E. Alexander

doi:10.1176/jnp.16.3.320

A distinctive interaction between chronic anxiety and problem solving in asymptomatic APOE e4 homozygotes

Richard J. Caselli, Eric M. Reiman, Joseph G. Hentz, David Osborne, Gene E. Alexander

Neurology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We correlated measures of problem solving (Wisconsin Card Sorting Test [WCST] categories, total errors, and perseverative errors) and chronic anxiety (Personality Assessment Inventory Anxiety Scale [ANX]) in asymptomatic apolipoprotein E (APOE) e4 homozygotes (HMZs), heterozygotes, and noncarriers (NC) (n = 42 in each group) matched for age, education, and gender. Differences between HMZ and NC in the slope of the regression of WCST scores on ANX reached statistical significance on all three WCST measures. Chronic anxiety adversely affects cognitive skills in all groups, and is associated with significantly greater decline in problem solving skills in cognitively normal APOE e4 HMZ.

Original language	English (US)
Pages (from-to)	320-329
Number of pages	10
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	16
Issue number	3
DOIs	https://doi.org/10.1176/jnp.16.3.320
State	Published - 2004

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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abstract = "We correlated measures of problem solving (Wisconsin Card Sorting Test [WCST] categories, total errors, and perseverative errors) and chronic anxiety (Personality Assessment Inventory Anxiety Scale [ANX]) in asymptomatic apolipoprotein E (APOE) e4 homozygotes (HMZs), heterozygotes, and noncarriers (NC) (n = 42 in each group) matched for age, education, and gender. Differences between HMZ and NC in the slope of the regression of WCST scores on ANX reached statistical significance on all three WCST measures. Chronic anxiety adversely affects cognitive skills in all groups, and is associated with significantly greater decline in problem solving skills in cognitively normal APOE e4 HMZ.",

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AB - We correlated measures of problem solving (Wisconsin Card Sorting Test [WCST] categories, total errors, and perseverative errors) and chronic anxiety (Personality Assessment Inventory Anxiety Scale [ANX]) in asymptomatic apolipoprotein E (APOE) e4 homozygotes (HMZs), heterozygotes, and noncarriers (NC) (n = 42 in each group) matched for age, education, and gender. Differences between HMZ and NC in the slope of the regression of WCST scores on ANX reached statistical significance on all three WCST measures. Chronic anxiety adversely affects cognitive skills in all groups, and is associated with significantly greater decline in problem solving skills in cognitively normal APOE e4 HMZ.

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A distinctive interaction between chronic anxiety and problem solving in asymptomatic APOE e4 homozygotes

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