A disposable flexible skin patch for clinical optical perfusion monitoring at multiple depths

Dana L. Farkas, Noah J. Kolodziejski, Christopher J. Stapels, Daniel R. McAdams, Daniel E. Fernandez, Matthew J. Podolsky, James F. Christian, Brent B. Ward, Mark Vartarian, Stephen E. Feinberg, Seung Yup Lee, Urmi Parikh, Mary Ann Mycek, Michael J. Joyner, Christopher P. Johnson, Norman A. Paradis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Stable, relative localization of source and detection fibers is necessary for clinical implementation of quantitative optical perfusion monitoring methods such as diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS). A flexible and compact device design is presented as a platform for simultaneous monitoring of perfusion at a range of depths, enabled by precise location of optical fibers in a robust and secure adhesive patch. We will discuss preliminary data collected on human subjects in a lower body negative pressure model for hypovolemic shock. These data indicate that this method facilitates simple and stable simultaneous monitoring of perfusion at multiple depths and within multiple physiological compartments.

Original languageEnglish (US)
Title of host publicationOptical Diagnostics and Sensing XVI
Subtitle of host publicationToward Point-of-Care Diagnostics
EditorsGerard L. Cote
PublisherSPIE
ISBN (Electronic)9781628419498
DOIs
StatePublished - 2016
EventOptical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics - San Francisco, United States
Duration: Feb 15 2016Feb 16 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9715
ISSN (Print)1605-7422

Other

OtherOptical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics
CountryUnited States
CitySan Francisco
Period2/15/162/16/16

Keywords

  • DCS
  • DRS
  • Optical perfusion monitoring
  • diffuse correlation spectroscopy
  • diffuse reflectance spectroscopy
  • hemorrhagic shock
  • noninvasive

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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