A diamond-based electrode for detection of neurochemicals in the human brain

Kevin E. Bennet, Jonathan R. Tomshine, Hoon Ki Min, Felicia S. Manciu, Michael P. Marsh, Seungleal B. Paek, Megan L. Settell, Evan N. Nicolai, Charles D. Blaha, Abbas Z. Kouzani, Su Youne Chang, Kendall H. Lee

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Deep brain stimulation (DBS), a surgical technique to treat certain neurologic and psychiatric conditions, relies on pre-determined stimulation parameters in an open-loop configuration. The major advancement in DBS devices is a closed-loop system that uses neurophysiologic feedback to dynamically adjust stimulation frequency and amplitude. Stimulation-driven neurochemical release can be measured by fast-scan cyclic voltammetry (FSCV), but existing FSCV electrodes rely on carbon fiber, which degrades quickly during use and is therefore unsuitable for chronic neurochemical recording. To address this issue, we developed durable, synthetic boron-doped diamond-based electrodes capable of measuring neurochemical release in humans. Compared to carbon fiber electrodes, they were more than two orders-of-magnitude more physically-robust and demonstrated longevity in vitro without deterioration. Applied for the first time in humans, diamond electrode recordings from thalamic targets in patients (n = 4) undergoing DBS for tremor produced signals consistent with adenosine release at a sensitivity comparable to carbon fiber electrodes. (Clinical trials # NCT01705301).

Original languageEnglish (US)
Article number102
JournalFrontiers in Human Neuroscience
Issue numberMAR2016
StatePublished - Mar 15 2016


  • Carbon fiber microelectrode
  • Deep brain stimulation (DBS)
  • Diamond-based electrode
  • Dopamine
  • Fast scan cyclic voltammetry (FSCV)
  • Neuromodulation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience


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