A diagnostic marker to discriminate childhood apraxia of speech from speech delay: Ii. validity studies of the pause marker

Lawrence D. Shriberg, Edythe A. Strand, Marios Fourakis, Kathy J. Jakielski, Sheryl D. Hall, Heather B. Karlsson, Heather L. Mabie, Jane L. McSweeny, Christie M. Tilkens, David L. Wilson

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11 Scopus citations

Abstract

Purpose: The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS). Method: PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts with idiopathic and neurogenetic CAS, adult-onset apraxia of speech and primary progressive apraxia of speech, and idiopathic speech delay. Results: Adjusted for questionable specificity disagreements with a pediatric Mayo Clinic diagnostic standard, the estimated sensitivity and specificity, respectively, of the PM were 86.8% and 100% for the CAS cohort, yielding positive and negative likelihood ratios of 56.45 (95% confidence interval [CI]: [1.15, 2763.31]) and 0.13 (95% CI [0.06, 0.30]). Specificity of the PM for 4 cohorts totaling 205 participants with speech delay was 98.5%. Conclusion: These findings are interpreted as providing support for the PM as a near-conclusive diagnostic marker of CAS.

Original languageEnglish (US)
Pages (from-to)S1118-S1134
JournalJournal of Speech, Language, and Hearing Research
Volume60
Issue number4
DOIs
StatePublished - Apr 1 2017

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ASJC Scopus subject areas

  • Language and Linguistics
  • Linguistics and Language
  • Speech and Hearing

Cite this

Shriberg, L. D., Strand, E. A., Fourakis, M., Jakielski, K. J., Hall, S. D., Karlsson, H. B., Mabie, H. L., McSweeny, J. L., Tilkens, C. M., & Wilson, D. L. (2017). A diagnostic marker to discriminate childhood apraxia of speech from speech delay: Ii. validity studies of the pause marker. Journal of Speech, Language, and Hearing Research, 60(4), S1118-S1134. https://doi.org/10.1044/2016_JSLHR-S-15-0297