A cross-sectional study of vitamin intake in postoperative non-small cell lung cancer patients

Aminah Jatoi, Benedict D T Daly, Gertrude Kramer, Joel B. Mason

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background and Objectives: This cross-sectional study of postoperative non-small cell lung cancer (NSCLC) patients examined possible effects of vitamin intake and folate status on disease-free survival. Methods: Supplemental vitamin usage, dietary vitamin intake (Willett Food Frequency Questionnaire), red blood cell (RBC) folate, and serum folate concentrations were assessed in patients with a history of NSCLC. Exclusion criteria included factors that alter folate status or that are associated with altered nutritional habits: (1) evidence of cancer on history, physical, or chest radiograph; (2) tobacco, alcohol ingestion (>2 drinks/day), or cancer treatment within 3 months; (3) use of folate antagonists; and (4) age <60 years. Results: 36 subjects were evaluated. The median disease-free censored survival was 24 months (range 4-41). Nineteen of 36 patients (53%) reported vitamin supplementation. Vitamin users had a longer median censored survival compared with nonusers (41 months versus 11 months; P = 0.002). With adjustment for cancer stage, the association between RBC folate and censored survival (r 0.35; P = 0.055) and between serum folate and censored survival (r = 0.32; P = 0.083) approached statistical significance. Conclusions: NSCLC patients who took vitamin supplements were more likely to be long-term survivors in the patients studied; a similar trend toward long-term survival was seen among patients with higher circulating folate concentrations.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalJournal of Surgical Oncology
Volume68
Issue number4
StatePublished - Aug 1998
Externally publishedYes

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Folic Acid
Vitamins
Non-Small Cell Lung Carcinoma
Cross-Sectional Studies
Survival
Disease-Free Survival
Eating
Erythrocytes
Neoplasms
Serum
Habits
Tobacco
Survivors
Thorax
History
Alcohols

Keywords

  • Cancer prevention
  • Folate
  • Non-small cell lung cancer
  • Nutrition
  • Vitamin supplementation

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

A cross-sectional study of vitamin intake in postoperative non-small cell lung cancer patients. / Jatoi, Aminah; Daly, Benedict D T; Kramer, Gertrude; Mason, Joel B.

In: Journal of Surgical Oncology, Vol. 68, No. 4, 08.1998, p. 231-236.

Research output: Contribution to journalArticle

Jatoi, Aminah ; Daly, Benedict D T ; Kramer, Gertrude ; Mason, Joel B. / A cross-sectional study of vitamin intake in postoperative non-small cell lung cancer patients. In: Journal of Surgical Oncology. 1998 ; Vol. 68, No. 4. pp. 231-236.
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abstract = "Background and Objectives: This cross-sectional study of postoperative non-small cell lung cancer (NSCLC) patients examined possible effects of vitamin intake and folate status on disease-free survival. Methods: Supplemental vitamin usage, dietary vitamin intake (Willett Food Frequency Questionnaire), red blood cell (RBC) folate, and serum folate concentrations were assessed in patients with a history of NSCLC. Exclusion criteria included factors that alter folate status or that are associated with altered nutritional habits: (1) evidence of cancer on history, physical, or chest radiograph; (2) tobacco, alcohol ingestion (>2 drinks/day), or cancer treatment within 3 months; (3) use of folate antagonists; and (4) age <60 years. Results: 36 subjects were evaluated. The median disease-free censored survival was 24 months (range 4-41). Nineteen of 36 patients (53{\%}) reported vitamin supplementation. Vitamin users had a longer median censored survival compared with nonusers (41 months versus 11 months; P = 0.002). With adjustment for cancer stage, the association between RBC folate and censored survival (r 0.35; P = 0.055) and between serum folate and censored survival (r = 0.32; P = 0.083) approached statistical significance. Conclusions: NSCLC patients who took vitamin supplements were more likely to be long-term survivors in the patients studied; a similar trend toward long-term survival was seen among patients with higher circulating folate concentrations.",
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