A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

Casey Cook; Leonard Petrucelli

doi:10.1016/j.bbadis.2009.01.012

A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

Casey Cook, Leonard Petrucelli

Neuroscience

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.

Original language	English (US)
Pages (from-to)	664-675
Number of pages	12
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1792
Issue number	7
DOIs	https://doi.org/10.1016/j.bbadis.2009.01.012
State	Published - Jul 2009

Keywords

Aggregation
Alpha-synuclein
DJ-1
Leucine-rich repeat kinase 2
Lewy bodies
Parkin
Parkinson's disease
Substantia nigra
Ubiquitin ligase
Ubiquitin proteasome system

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.bbadis.2009.01.012

Cite this

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title = "A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease",

abstract = "The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.",

keywords = "Aggregation, Alpha-synuclein, DJ-1, Leucine-rich repeat kinase 2, Lewy bodies, Parkin, Parkinson's disease, Substantia nigra, Ubiquitin ligase, Ubiquitin proteasome system",

author = "Casey Cook and Leonard Petrucelli",

note = "Funding Information: This work was supported by the Mayo Clinic Foundation and funding by NIA R01-AG-026251-01, NINDS NS55698, and NIA AG17216 and NINDS NS59363J1.",

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AU - Petrucelli, Leonard

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AB - The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.

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KW - Leucine-rich repeat kinase 2

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KW - Substantia nigra

KW - Ubiquitin ligase

KW - Ubiquitin proteasome system

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A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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