A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

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Abstract

The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.

Original languageEnglish (US)
Pages (from-to)664-675
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1792
Issue number7
DOIs
StatePublished - Jul 2009

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Proteasome Endopeptidase Complex
Ubiquitin
Parkinson Disease
Pathology
Therapeutics
Direction compound

Keywords

  • Aggregation
  • Alpha-synuclein
  • DJ-1
  • Leucine-rich repeat kinase 2
  • Lewy bodies
  • Parkin
  • Parkinson's disease
  • Substantia nigra
  • Ubiquitin ligase
  • Ubiquitin proteasome system

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

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title = "A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease",
abstract = "The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate.",
keywords = "Aggregation, Alpha-synuclein, DJ-1, Leucine-rich repeat kinase 2, Lewy bodies, Parkin, Parkinson's disease, Substantia nigra, Ubiquitin ligase, Ubiquitin proteasome system",
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