@article{0cbe10a56ef1464f9cdbe2a4d152db38,
title = "A CRISPR reimagining: New twists and turns of CRISPR beyond the genome-engineering revolution",
abstract = "Despite its explosive applications in genome engineering, CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) has been developed into a versatile tool beyond its well-known nuclease function. In this prospect article, we summarize a few exciting “off-label” applications of CRISPR including manipulating DNA sequences, visualizing chromosomal loci in living cells, and modulating transcription and chromatin structures. These novel applications will likely elevate CRISPR tools into yet another level of sophistication and diversity, leading to many more exciting cell biological discoveries.",
keywords = "CRISPR, designer nuclease, genome engineering",
author = "Plummer, {Robert J.} and Yi Guo and Ying Peng",
note = "Funding Information: We thank Cassandra A. Kersten and Elise N. Sloey for assistant of manuscript preparation. The project was funded by the Mayo Clinic Graduate Research Employment Program for Robert J. Plummer, a Mayo Clinic New Investigator Startup Fund, a Richard F. Emslander Career Development Award, a Mayo Clinic Center for Biomedical Discovery Platform Grant, and a Fibrolamellar Cancer Foundation Research Grant to Dr. Yi Guo. Funding Information: Mayo Clinic New Investigator Startup Fund; Mayo Clinic Graduate Research Employment Program; Richard F. Emslander Career Development Award; Fibrolamellar Cancer Foundation Research Grant; Mayo Clinic Center for Biomedical Discovery Platform Grant Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2018",
month = feb,
doi = "10.1002/jcb.26406",
language = "English (US)",
volume = "119",
pages = "1299--1308",
journal = "Journal of supramolecular structure and cellular biochemistry",
issn = "0730-2312",
publisher = "Wiley-Liss Inc.",
number = "2",
}