A CRISPR reimagining: New twists and turns of CRISPR beyond the genome-engineering revolution

Robert J. Plummer, Yi D Guo, Ying Peng

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Despite its explosive applications in genome engineering, CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) has been developed into a versatile tool beyond its well-known nuclease function. In this prospect article, we summarize a few exciting “off-label” applications of CRISPR including manipulating DNA sequences, visualizing chromosomal loci in living cells, and modulating transcription and chromatin structures. These novel applications will likely elevate CRISPR tools into yet another level of sophistication and diversity, leading to many more exciting cell biological discoveries.

Original languageEnglish (US)
Pages (from-to)1299-1308
Number of pages10
JournalJournal of Cellular Biochemistry
Volume119
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • CRISPR
  • designer nuclease
  • genome engineering

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A CRISPR reimagining: New twists and turns of CRISPR beyond the genome-engineering revolution'. Together they form a unique fingerprint.

  • Cite this